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News - 2020


2020-06-05, NEWS

SciLifeLab Facilities used to identify fear-related genes in Great Danes

In a new study from the universities of Ohulu and Helsinki in Finland, published in Nature translational psychiatry, the exomes of 16 Great Dane dogs were sequenced using SciLifeLab’s National Genomics Infrastructure (NGI). The authors hope that this may provide a natural animal model for human anxieties. A genome-wide association study, GWAS, of 124 dogs, […]

2020-06-05, NEWS

World Environment Day June 5 – Environmental Highlights from SciLifeLab

Although our news feed has focused mainly on the ongoing COVID-19 research at SciLifeLab, our scientists and facilities are often involved in environmental research. Here are a few of our latest articles focusing on the environment!   New genetics study reveals unknown relationship between the Taiga and Tundra Bean Goose Enabled by the SciLifeLab National […]

2020-06-04, NEWS

Dead Sea scroll DNA sheds light on historic mystery

Facilitated by the SciLifeLab National Genomics Infrastructure (NGI), researchers from Sweden and Israel have analyzed DNA from 40 fragments belonging to the Dead Sea scrolls in order to find out the origin of the animals that provided skin for the scrolls. The DNA extraction from the more than 2,000-year-old scrolls was successful and the genetic […]

2020-06-04, NEWS

Mercodia donates robot to help increase COVID-19 testing

The Biotech company Mercodia donates a 2 000 000 SEK robot to KTH and SciLifeLab in an effort to speed up the COVID-19 testing.  After contacting STUNS Life science network it took only about an hour before a suitable environment, where the robot could be most useful, was found at SciLifeLab in Solna. “We bought […]

2020-06-03, NEWS

New national portal makes research data on COVID-19 accessible

Today sees the launch of a national data portal for research into COVID-19, coordinated by SciLifeLab and the Swedish Research Council. It will now be easier for researchers to find and share relevant research data. Advances in research into the coronavirus are largely driven by research data being rapidly shared around the world. The EU […]

2020-06-03, PRESS

Ny nationell portal tillgängliggör forskningsdata om covid-19

Idag lanseras en nationell dataportal för forskning om covid-19, koordinerad av SciLifeLab och Vetenskapsrådet. Det blir nu enklare för forskare att hitta och dela relevanta forskningsdata. Framsteg i forskningen kring coronaviruset drivs i hög grad av att forskningsdata snabbt kan delas världen över. EU-kommissionen synliggör därför forskningsdata och metadata från forskning om covid-19 på en […]

2020-06-02, NEWS

Cytiva associates tested for COVID-19 in collaboration with SciLifeLab

In a new collaboration between Cytiva, SciLifeLab , KI and KTH, Cytiva employees will be tested for COVID-19 infection using analysis methods developed by SciLifeLab and KTH. As well as evaluating the new method the testing will also help paint a more complete picture of the COVID-19 spread so far. Cytiva contributes with knowledge and […]

2020-05-27, NEWS

NGI awarded Chan Zuckerberg Initiative grant for nf-core project

The SciLifeLab National Genomics Infrastructure (NGI) has been awarded the high profile “Essential Open Source Software for Science” grant from the Chan Zuckerberg Initiative. The grant will be used to fund coordination and events for the Nextflow and nf-core projects. The second round of CZI Essential Open Source Software for Science (EOSS) grants have just […]

2020-05-27, NEWS

New genetics study reveals unknown relationship between the Taiga and Tundra Bean Goose

Enabled by the SciLifeLab National Genomics Infrastructure (NGI), researchers from Uppsala University, University of Oulu (Finland), and Wageningen University & Research (the Netherlands) studied the relationship between two species of geese, the Taiga Bean Goose, and the Tundra Bean Goose. Based on their results the authors argue that both groups should be treated as subspecies […]

2020-05-27, NEWS

SciLifeLab chairman Carl-Henrik Heldin appointed chair of ERC Committee

Six international top-level scientists have been invited by Mariya Gabriel, the European commissionaire for innovation, science, culture, education, and youth; to form the committee of chairmen that will appoint board members to the ERC scientific council. Carl-Henrik Heldin is one of six individuals that has been elected and will be chair of the Identification Committee […]

2020-05-26, NEWS

New method exposes DNA weak spots in the nucleus

Researchers led by SciLifeLab Fellow Magda Bienko (Karolinska Institutet) and Nicola Crosetto (SciLifeLab/Karolinska Institutet) have developed a new sequencing method that makes it possible to spatially map how DNA is organized in the nucleus. This makes it possible to reveal which regions are at a higher risk of mutations and DNA damage. Most cells in the […]

2020-05-20, NEWS

Donations enable additional COVID-19 research

The Einhorn Family Foundation and the Foundation for International Oncological Cooperation donates nearly 600 000 SEK to support COVID-19 research at Uppsala University and SciLifeLab. Some people develop severe immunological reactions when infected by the coronavirus, while others hardly display any symptoms at all. To help find out why that is, the Einhorn Foundation has […]

2020-05-19, NEWS

New potential treatment for multiple myeloma cancer

Researchers from SciLifeLab and Uppsala University have investigated if immunotherapy could potentially be used as a treatment for Multiple myeloma, a type of cancer that affects the plasma cells. The study was published in Nature Cancer Gene Therapy. Multiple myeloma (MM) is a cancer form that affects plasma cells and is characterized by dysregulation in […]

2020-05-14, NEWS

SciLifeLab COVID-19 testing up and running at high speed

Since the beginning of the corona pandemic, SciLifeLab, along with its host universities Uppsala University, Stockholm University, Karolinska Institutet and KTH Royal Institute of Technology, has participated in the ongoing battle, setting up large-scale COVID-19 testing and analysis capabilities, as well as facilitating research to gain better insights into the disease. The efforts have been […]

2020-05-12, NEWS

Hybridization between birds more common than previously thought

Facilitated by the SciLifeLab National Genomics Infrastructure (NGI), researchers from Uppsala University and Princeton University have been able to show that the beak morphology of Darwin’s finches has been affected by hybridization – gene exchange between two closely related species – something previously thought to be very rare. The study was published in Nature Ecology […]

2020-05-07, NEWS

The National Academy of Sciences elects SciLifeLab researcher Kerstin Lindblad-Toh

Uppsala University researcher and former SciLifeLab co-director Kerstin Lindblad-Toh is one of the newest additions to the National Academy of Sciences. The National Academy of Sciences is a prestigious organization with head office in Washington D.C., USA, and 2403 active members worldwide. It was founded in 1863 by Abraham Lincoln, and have since then housed […]

2020-05-07, NEWS

SciLifeLab launches national COVID-19 research program

A total of 67 COVID-19 research projects – on everything from virus diagnostics and high-throughput serology, to biomarkers, drug discovery and environmental virus profiling – are part of the national research program SciLifeLab is now launching together with Knut and Alice Wallenberg Foundation. The projects focus on combating the corona pandemic by leveraging the SciLifeLab infrastructure.

2020-05-06, NEWS

New study confirms that 10 percent of the Stockholm population has antibodies against SARS-CoV-2

In the beginning of April, approximately 10 percent of Stockholm’s population had, at one point, formed antibodies against the virus causing COVID-19; according to a new study done by researchers at KTH, SciLifeLab and KI. The researchers used home sample collection kits sent to 1000 random Stockholm residents between the age of 20-74 before Easter, […]

2020-05-06, PRESS

SciLifeLab lanserar nationellt forskningsprogram kring Covid-19

Totalt 67 forskningsprojekt kring Covid-19 – inom allt ifrån virusdiagnostik och serologi, till biomarkörer, läkemedelsutveckling och datamodeller – är del av det nationella forskningsprogram som SciLifeLab nu lanserar tillsammans med Knut och Alice Wallenbergs Stiftelse. Projekten fokuserar på att bekämpa coronapandemin med hjälp av den infrastruktur som finns vid SciLifeLab.

2020-05-06, NEWS

Per Ljungdahl (SU) appointed new SciLifeLab Campus Solna Director

Starting this week, Professor Per Ljungdahl (Stockholm University) will take on the new role as SciLifeLab Campus Solna (CS) Director. As CS Director, Per Ljungdahl is responsible for the joint research environment at Campus Solna, and he leads the site support, safety, and IT teams as well as the joint finances. Per was born in Stockholm […]

2020-04-30, NEWS

Researchers identify cells susceptible to infection by SARS-COV-2

An international group of scientists, with researchers from SciLifeLab, Stockholm University, Karolinska Institutet, and KTH Royal Institute of Technology, have identified which cells in the body that the new coronavirus (SARS-CoV-2) can infect. The results, published in Nature Medicine could lead to better treatment of the virus. Previous studies have shown that the spike protein […]

2020-04-30, NEWS

Helleday group awarded ERC Proof of Concept for new treatment for severe pneumonia and fibrosis

SciLifeLab researcher Thomas Helleday (Karolinska Institutet) and his group have been awarded the prestigious ERC Proof of Concept Grant, awarded by the European Research Council (ERC), for the fourth time. The grant will be used to develop new anti-inflammatory drugs for lung diseases such as pneumonia and fibrosis. The researchers now plan to further develop […]

2020-04-27, NEWS

CRISPRi used to select cyano-bacterium suitable for industrial use

Researchers from SciLifeLab have developed a new method to easily find cyanobacterium clones suitable for enhanced industrial purposes. Cyanobacteria are model organisms for photosynthesis but can also be used as sustainable sources of protein or producers of “nutraceuticals” in biotechnological applications, or as alternative fertilizers and bio-fuels. In a recent study, led by Paul Hudson […]

2020-04-23, NEWS

Researchers identify the cause of leaking blood vessels in eye diseases

Researchers from SciLifeLab and Uppsala University have discovered a vital step in the process that can lead to leaking blood vessels and harmful swelling in the eyes of patients with certain types of eye conditions. The results, published in eLife, could lead to safer treatment strategies. Aging and diabetes can cause leaking blood vessels to […]

2020-04-20, NEWS

International evaluation of SciLifeLab’s infrastructure in the form of a remote panel meeting

On April 20 to 22, an international committee of experts will participate in an online panel meeting as part of an evaluation of SciLifeLab’s infrastructure. The purpose of the evaluation is to ensure that SciLifeLab provides an up-to-date infrastructure with cutting-edge technologies for Swedish researchers. The meeting was originally planned to take place in Stockholm, but as […]

2020-04-17, NEWS

Shedding light on the mechanisms behind schizophrenia

Facilitated by the SciLifeLab National Genomics Infrastructure (NGI) and staff from the SciLifeLab Bioinformatics Platform (NBIS), researcher from Lund University, Chalmers University, Uppsala University, Karolinska Institutet (KI) and the University of North Carolina (UNC), USA, have revealed a new mechanism, involved in the development of schizophrenia. To understand how genes play a part in schizophrenia a […]

2020-04-14, NEWS

Testing wastewater to detect waves of COVID-19 infections

Henriksdal wastewater treatment plant. Photographer: Kari Kohvakka/Stockholm Vatten och Avfall.  Pandemic outbreaks can come in several waves, as occurred with the Hong Kong flu of 1968 and the so-called swine flu in 2009. Now, a group of scientists, among them researchers from KTH and SciLifeLab, will keep track of the COVID-19 developments by testing wastewater. […]

2020-04-14, NEWS

Danderyd Hospital staff will be tested for COVID-19 antibodies

In a new study, employees from Danderyd Hospital will be tested for antibodies against COVID-19 using the new serological test developed by researchers at KTH and the SciLifeLab Autoimmunity Profiling facility, among them, Peter Nilsson (SciLifeLab/KTH). It will be the first hospital to evaluate this new test that could verify if an individual has previously […]

2020-04-08, NEWS

COVID-19 on the agenda as Matilda Ernkrans visits SciLifeLab

Today on April 8, the Minister for Higher Education and Research in Sweden, Matilda Ernkrans, visited SciLifeLab and Karolinska Institutet for briefings on the ongoing initiatives to combat COVID-19, that could be so promptly set up due to the generous donation from Knut and Alice Wallenberg Foundation. SciLifeLab’s specialized instrumentation, expertise and national network enabled a rapid shift to coronavirus-focused operations. […]

2020-04-08, NEWS

SciLifeLab coordinates major efforts in diagnostics and research on the Coronavirus

SciLifeLab now takes a holistic approach to life science efforts in the ongoing corona pandemic. In order to achieve progress rapidly, promising research projects receive expeditious funding from Knut and Alice Wallenberg Foundation, and traditionally competing research is organized as a team effort. As a step towards fighting COVID-19, SciLifeLab is now coordinating research efforts across the […]

2020-04-08, PRESS

SciLifeLab samordnar storsatsning på diagnostik och forskning om Coronaviruset

(PRESSMEDDELANDE) Det universitetsdrivna forskningscentret SciLifeLab tar nu ett helhetsgrepp på biovetenskapliga insatser kopplade till den pågående pandemin orsakad av coronaviruset SARS-CoV-2. För att nå snabba framsteg får lovande forskningsprojekt snabb finansiering av Knut och Alice Wallenbergs Stiftelse och traditionellt konkurrerande forskning lyfts till en laginsats. Som ett steg i kampen mot covid-19 kommer SciLifeLab (Science […]

2020-04-08, NEWS

1000 anonymous self-sampling kits for COVID-19 distributed among Stockholm residents

Photos: the SciLifeLab Plasma Profiling facility and Jochen Schwenk. On Wednesday, April 8, 1000 anonymous self-sampling kits for COVID-19 were distributed in Stockholm. Jochen Schwenk (professor in Translational Proteomics at KTH Royal Institute of Technology), researcher at SciLifeLab and Director of SciLifeLab’s Plasma Profiling facility, is one of the researchers involved in the initiative. Self-sampling kits have now been distributed […]

2020-04-06, NEWS

SciLifeLab researcher Sara Mangsbo awarded the ÅForsk’s scholarship

SciLifeLab researcher Sara Mangsbo (UU) has been appointed one of Sweden’s ten most innovative entrepreneurs 2020 by the Swedish Incubators & Science Parks (SISP) and ÅForsk. This means she will receive the ÅForsk’s entrepreneur Scholarship of 200 000 SEK to further develop her research project, Immune Gas Pedal (IMMGAP), a platform that can help make […]

2020-04-03, NEWS

Large International COVID19 consortium

SciLifeLab researcher Petter Brodin (KI) has been appointed Swedish coordinator for the international consortium The COVID Human Genetic Effort. Their goal is to identify and study young patients (<50years of age), without underlying conditions, developing severe COVID-19 and requiring intensive care, in order to search for possible inborn errors of immunity. “We will share information […]

2020-04-03, NEWS

Material enabling scale-up of COVID-19 analyses has now arrived / Material som möjliggör uppskalning av COVID-19-analyser har nu kommit

(Swedish below) The test material that will allow scientists at Karolinska Institutet and SciLifeLab to perform 5,000 analyses a day on patient samples has now arrived. The delivery was enabled by, among other things, the collaboration with a research institute in Shenzhen, China, and the generous donation made by Knut and Alice Wallenberg Foundation. On Wednesday […]

2020-04-01, NEWS

A new atlas of human metabolism

The new Metabolic Atlas, which is part of the Human Protein Atlas (HPA), was recently described in Science Signaling. The map enables exploration of the human metabolism and is the most extensive metabolism map to date. Within the hundreds of new interactive 2D and 3D maps, information about thousands of reactions, compounds and human metabolism […]

2020-04-01, NEWS

Evolutionary genetics of canine corona virus in Swedish dogs

Enabled by the SciLifeLab National Genomics Infrastructure (NGI), researchers have investigated Canine respiratory coronavirus (CRCoV) in Swedish dogs. CRCoV is the main cause of upper respiratory infection in dogs in Sweden but the understanding of its global prevalence, pathology, and genetic characteristics is still dim. In a recent study, enabled by the SciLifeLab National Genomics […]

2020-03-31, NEWS

SciLifeLab researcher Johan Elf receives an ERC Advanced Grant

Today, the Swedish Research Council announced that Johan Elf (SciLifeLab/Uppsala University), is awarded an ERC Advanced Grant. He is one of 185 researchers who receives the grant, whereof only six are working in Sweden. The researchers will share a total amount of 450 million Euro. “I am very happy that we can start this exciting and […]

2020-03-31, NEWS

Large number of submissions to SciLifeLab COVID-19 call

The SciLifeLab Open Call for COVID-19-related Proposals is now closed. We have received an astonishing 285 submissions and will now commence the process of evaluating the proposals, identifying synergies and deciding which initiatives to support through this funding. Additional updates regarding the call will follow as information becomes available.

2020-03-26, NEWS

Cancer cells makes themselves vulnerable to new drugs

Researchers from SciLifeLab and Uppsala University have discovered a way to use the rapid mutation rate in cancer cells as a weapon against tumours. A new substance has shown promising results in both animal and human cancer cells. The results are published in Nature Communications. Normally cancer cells quickly alter their DNA, making them hard […]

2020-03-26, NEWS

Revealing new mechanisms of STAT3 inhibition

Facilitated by the SciLifeLab Chemical Biology Consortium Sweden (CBCS), researchers from Sweden and Canada have identified novel ways to inhibit STAT3 activity in cancer cells while revealing new mechanistic understanding of STAT3 biology. Transcription factor STAT3 plays an important role during cancer development and progression and has, because of this, become a popular target for […]

2020-03-25, NEWS

SciLifeLabs handlingsplan för COVID-19 lanserad – med utlysning till forskarsamhället / SciLifeLab COVID-19 Action Plan launched with open call to the research community

[Swe] Vilka steg tar SciLifeLab i kampen mot coronaviruset? De kan delas in i två huvuddelar – fokuserade på att testa och analysera SARS-Cov-2-viruset, och att bekämpa coronapandemin – som presenteras i den nyligen lanserade handlingsplanen. [Eng] What steps are SciLifeLab taking in the battle against the corona virus? They can be divided into two main parts – focused on testing the SARS-Cov-2 virus and combating the corona pandemic – which are presented in the newly launched Action Plan.

2020-03-23, PRESS

SciLifeLab bidrar till uppskalning av diagnostisering och analys av COVID-19

Igår, den 22 mars 2020, meddelande Knut och Alice Wallenbergs Stiftelse att de omgående anslår 50 miljoner kronor till akademiska laboratorier på SciLifeLab, Karolinska Institutet och Uppsala universitet för att bistå i sjukvårdens uppskalning av provtagning avseende coronavirussjukdomen COVID-19. ”SciLifeLab:s forskare vill och är redo att bidra i arbetet med den pågående COVID-19-pandemin på flera olika vis, både på kort sikt och längre fram.”

2020-03-20, NEWS

SciLifeLab infrastructure facilities prioritize COVID-19 projects

SciLifeLab service facilities are now encouraged to prioritize projects regarding COVID-19. As a national, government-funded research infrastructure in Sweden, SciLifeLab can make advanced technologies and expertise available to support researchers working on COVID-19. As always, feasibility and quality are key when our facilities approve applications for service. Are you conducting a COVID-19 project and unsure of which infrastructure […]

2020-03-19, NEWS

DNA from 1/3 of the Baltic Sea plankton catalogued

An international collaboration, led by Anders Andersson (SciLifeLab/KTH), has assembled the genomes of hundreds of bacterioplankton species from the Baltic Sea. In the study, published in Communications Biology, the researchers show that by having this large number of genomes from the same ecosystem, the ecological niche of individual species can be predicted directly from their […]

2020-03-16, NEWS

SciLifeLab releases 10-year strategy: Strong focus on technology- and data-driven life science

Ten years has passed since SciLifeLab was first launched and the importance of life science to all aspects of human life and society is ever so evident – not least from the ongoing pandemic crisis. SciLifeLab’s new Roadmap for the decade ahead pinpoints how our research infrastructure can be advanced and leveraged in creating multidisciplinary, […]

2020-03-11, NEWS

Cryo-EM reveals unexpected diversity of Photosystems

Researchers from SciLifeLab have reconstructed the atomic models of new forms of Photosystem I in collaboration with scientists from Tsinghua University (China) and Tel Aviv University (Israel). The studies, published in two Nature Plants articles, expand on the fundamental understanding of how bioenergetic complexes are assembled and regulated in the photosynthetic membranes of cyanobacteria and […]

2020-03-06, NEWS

One step closer to understand the human brain

An international team of scientists led by researchers from SciLifeLab and Karolinska Institutet has launched a comprehensive overview of all proteins expressed in the brain, providing neuroscience and medical research with a tool to explore proteins in different parts of the brain controlling basic and complex brain functions. The open-access database offers medical researchers an […]

2020-03-04, NEWS

Science & SciLifeLab Prize for Young Scientists – Application Period Open

In order to promote young scientists early in their career, SciLifeLab has engaged in a collaboration with AAAS and Science magazine to award an annual prize in the area of life science for the best PhD thesis work. An essay based on the thesis is submitted to the editorial board of Science and four winners […]

2020-03-03, NEWS

SciLifeLab researcher Petter Brodin awarded the Göran Gustafsson Prize

SciLifeLab researcher Petter Brodin (Karolinska Institutet), is awarded the prestigious Göran Gustafsson Prize in medicine for his “pioneering analysis of the early development of the human immune system”. “Our goal is to optimize the development of all children and find out what is a healthy start for them. There are many epidemiological studies showing that […]

2020-03-02, NEWS

New method sheds light on the role of RNA in chromatin regulation

Researchers from Karolinska Institutet, SciLifeLab and RIKEN (Japan) have developed a new method that can generate maps of RNA and chromatin interactions in the nucleus. This is particularly useful when studying how gene expression is regulated in different cells and tissues. Inside the mammalian genome, thousands of noncoding RNA:s can be found. Once transcribed, these […]

2020-02-25, NEWS

New rapid COVID-19 detection method developed

Researchers from Shenyang, Huazhong and SciLifeLab have developed a rapid colorimetric detection method for the COVID-19 coronavirus (iLACO). The approach is based on RT-LAMP (loop-mediated isothermal amplification) and allows a fast detection using a visual colorimetric assay (pink to yellow). The approach can detect down to 10 molecules of virus RNA in 15 to 40 […]

2020-02-25, NEWS

Creating cartoons to communicate science – Jonas Nørskov Søndergaard challenges what a scientific journal could be

Jonas Nørskov Søndergaard is, apart from being a cancer researcher at SciLifeLab, moonlighting with creating his own academic journal. What he thought was going to be an instant success turned out to require a lot more work, however. What seems to be a million steps awaits when entering the 1920’s apartment building, with its fair-faced […]

2020-02-24, NEWS

Revealing new details about P. infestans reproductive system

Facilitated by the SciLifeLab National Genomics Infrastructure (NGI) researchers from the Swedish University of Agricultural Sciences (SLU) have investigated the sexual reproduction system of the “potato late blight” pathogen Phytophthora infestans, one of the most notorious plant pathogens known today. Phytophthora infestans is a fungal-like filamentous pathogen that can infect many species in the Solanaceae […]

2020-02-18, NEWS

SciLifeLab Fellows appointed Future Research Leaders by the SSF

The Swedish Foundation for Strategic Research (SSF) has appointed the seventh generation of Future Research Leaders (FFL). From the 227 applications, 10 men and 10 women were selected, among them SciLifeLab Fellows Simon Elsässer (Karolinska Institutet) and Mikael Sellin (Uppsala University). The goal is to support and promote young scientists into becoming the future leaders […]

2020-02-17, NEWS

Dingos evolved from domesticated Indonesian village dogs

According to a study, led by SciLifeLab researcher Peter Savolainen (KTH), the Australian dingo derives from domesticated dogs. Scientists have long suspected this but up until now, no genomic studies to confirm the hypothesis have been conducted. Their migration to Australia began 9,900 years ago when they split off from their ancestors, the Indonesian village […]

2020-02-14, NEWS

The nf-core community provides computational pipelines

To help researchers analyse their data in a reproducible and accessible manner, researchers at SciLifeLab have created a community called nf-core, which provides best-practice bioinformatics analysis pipelines for use across any institute or research facility. The capacity for data-generation within life-sciences is growing rapidly, and with it the need for analysis methods to be FAIR […]

2020-02-13, NEWS

Researchers unveil the mechanism behind malaria sugar uptake

Researchers from SciLifeLab, among them SciLifeLab Fellow Lucie Delemotte (KTH),  and Stockholm University have unveiled the mechanism behind the malaria parasite sugar uptake, something that could be useful in the hunt for new drugs. Malaria is responsible for killing almost half a million people every year, according to the WHO. The Malaria parasite (Plasmodium falciparum) needs, […]

2020-02-05, NEWS

Whole genome sequencing from just six nuclei

Enabled by the SciLifeLab Microbial Single Cell Genomics facility (MSCG), National Genomics Infrastructure (NGI) and National Bioinformatics Infrastructure (NBIS), researchers from Uppsala University have developed a new and more effective way to sequence genomes from organisms that are otherwise hard to sequence. The reasons why some organisms are harder to sequence are usually because of […]

2020-01-29, NEWS

Supposedly “lethal” mutation makes bacteria resistant to rifampicin

Facilitated by the former SciLifeLab facility Mass Spectrometry-based Proteomics in Uppsala, researchers from Uppsala University have discovered how antibiotic-resistant tuberculosis manages to survive even though it carries a mutation that should kill it. Every year, tuberculosis (TB) is responsible for the deaths of 1.5 million people worldwide. It is normally treated with a combination of […]

2020-01-27, NEWS

Intestinal epithelial cells rarely tricked by Salmonella’s evasiveness

A study by researchers from SciLifeLab and ETH Zurich, Switzerland, sheds light on the defense mechanisms restricting Salmonella Typhimurium (S. Tm) from disseminating to systemic organs from the intestinal tract, following oral infection. Inflammasomes – signaling complexes that assemble when host cells detect invading pathogens – can prevent systemic dissemination of bacteria from the intestinal […]

2020-01-17, NEWS

New cheap drug targets therapy resistance in acute myeloid leukaemia

A common and inexpensive drug can be used to counteract treatment resistance in acute myeloid leukemia (AML), one of the most common blood cancer forms in adults, according to a study led by researchers from SciLifeLab and Karolinska Institutet. The study was published in the medical journal EMBO Molecular Medicine and the researchers will now […]

2020-01-14, NEWS

Coordinating safety – Jona Gudjonsdottir helps scientists stay safe

To help researchers work safely and avoid making the same life threatening mistakes she has made in the lab, Jona Gudjonsdottir uses her lifelong experience from various laboratories in her role as Lab Safety Coordinator at SciLifeLab. Before learning what Lab Safety Coordinator Jona Gudjonsdottir actually does for a living, for someone working at SciLifeLab […]

2020-01-13, NEWS

Sleep deprivation might increase the risk of Alzheimer’s disease

Facilitated by the SciLifeLab National Genomics Infrastructure (NGI), researchers have discovered that the blood levels of tau – a biomarker for Alzheimer’s disease – increases when the test subjects were deprived of just one night of sleep. Tau is a protein found in neurons that can form tangles and accumulate in the brains of people with […]

2020-01-08, NEWS

Computer algorithm finds new therapeutic target for neuroblastoma

Based on a new algorithm, TargetTranslator, researchers from SciLifeLab were able to identify a new therapeutic target for neuroblastoma, a form of cancer in the sympathetic nervous system. The algorithm integrates data from tumour biobanks, pharmacological databases, and cellular networks. Neuroblastoma is mainly affecting young children and is responsible for 15 percent of all childhood […]