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News - 2019

2019-12-19, NEWS

Immune cell map arms researchers with new tool to fight deadly diseases

A first-ever map of the human body’s immune cells has been created by scientists in Sweden, providing medical research with a detailed description of the proteins in human blood. The open-access database offers medical researchers an unprecedented resource in the search for treatments for diseases. Published today in the journal Science, the Blood Atlas resource […]

2019-12-19, NEWS

Anti-inflammatory drug project exits SciLifeLab Drug Discovery and Development platform

After a four-year joint quest with the SciLifeLab Drug Discovery and Development platform for a new treatment for inflammatory conditions, Susanne Lindquist and Olle Hernell from Umeå University today reached their final project milestone. Around the corner awaits trials to bring their therapeutic antibody targeting bile salt-stimulated lipase to patients. When Olle Hernell, now Professor […]

2019-12-18, NEWS

Arteria could help tackle the explosive growth of sequencing data

Software developers and bioinformaticians from the SciLifeLab National Genomics Infrastructure (NGI Uppsala) and the Clinical Genomics facility (Uppsala) have developed a new automation system, called Arteria, that aims to tackle the problems associated with the explosive growth in sequencing data world wide, such as the need for automated solutions for data processing and analysis. Nucleotide […]

2019-12-17, NEWS

Sara Mangsbo is programming T-cells in the fight against cancer at the DDDP

SciLifeLab researcher Sara Mangsbo (UU) and her team has, together with SciLifeLab’s Drug Discovery and Development Platform (DDDP), developed a unique platform capable of programming specialized T-cells in the fight against cancer. Using the immune system to attack tumor cells is one of the hottest areas in cancer drug discovery research at the moment. Immune […]

2019-12-16, NEWS

New approach sheds light on the developing human heart

Facilitated by SciLifeLab’s Bioinformatics Platform (NBIS), National Genomics Infrastructure (NGI) and Eukaryotic Single Cell Genomics platform (ESCG), researcher from SciLifeLab have used a new approach to investigate the gene expression in the developing human heart in order to increase understanding of the genetic programs that are active during the developmental stage. This provides greater insights […]

2019-12-13, NEWS

Prize symposium 2019 – Roads to Research Excellence

More than 150 PhD students and scientists had gathered in anticipation of an interesting day with inspiring talks from the winners of this year’s Science & SciLifeLab Prize for Young Scientists. The symposium, Roads to Research Excellence, took place on december 12. It has been a busy week for the winners of the 2019 Science […]

2019-12-13, NEWS

Ulf Gyllensten receives the Rudbeck medal

Professor Ulf Gyllensten, researcher at SciLifeLab/Uppsala University and Platform Director of the SciLifeLab Genomics platform has been selected to receive the Rudbeck medal. The award is given by Uppsala University for extraordinarily outstanding research. Ulf Gyllensten receives the medal for his studies human genetics and molecular epidemiology. Read the full press release by Uppsala University

2019-12-12, NEWS

SciLifeLab Director on the national life science strategy

”Today’s rapid developments in life science makes for incredible opportunities, but also poses challenges. This is the time to be on our toes, otherwise we risk falling far behind.” This was the final statement by Ibrahim Baylan, Sweden’s Minister for Enterprise and Innovation as the government’s national life science strategy was presented during a press […]

2019-12-11, NEWS

Shedding light on the genetic variation between sexes

Facilitated by SciLifeLab’s Bioinformatics Platform (NBIS) and National Genomics Infrastructure (NGI), researchers from SciLifeLab and Uppsala University shed light on the genetic “tug-of-war” that acts between sexes to maintain variation. A mechanism that scientists have long struggled to understand. Important traits, such as lifespan or metabolism, can sometimes differ between the sexes. In many species, […]

2019-12-11, NEWS

ImJoy: a new computational platform for deep learning

Researchers from SciLifeLab have developed a new online platform to address the pressing need for publically available deep learning bioinformatic tools – tools that can learn how to make correct decisions by themselves based on large data sets. The new platform, known as ImJoy, facilitates the development and sharing of advanced data analysis tools, especially […]

2019-12-10, NEWS

The MR-Bi – new bioinformatics tool to support curriculum design

In October 2017, the SciLifeLab Bioinformatics platform (NBIS) hosted a 2-day educational workshop involving bioinformatics teachers from across Sweden. The workshop was facilitated by Jessica Lindvall (NBIS/Stockholm University) and her collaborative team consisting of Rochelle E. Tractenberg (Georgetown University, USA), Teresa K. Attwood (University of Manchester, UK) and Allegra Via (National Research Council, Italy). The […]

2019-12-05, NEWS

Swedish Cancer Society visits SciLifeLab

his morning, more than 70 representatives from the Swedish Cancer Society visited SciLifeLab, including Secretary-General Ulrika Årehed Kågström. SciLifeLab Director, Olli Kallioniemi, welcomed the group and gave a brief introduction of SciLifeLab’s past, presence and future.  “The whole point of SciLifeLab is to connect life sciences with the latest technology. We have around 1300 individual […]

2019-12-05, NEWS

AI solutions crowd-sourced for the Human Protein Atlas

SciLifeLab researchers, led by Emma Lundberg (SciLifeLab/KTH), organized a competition called the Human Protein Atlas (HPA) Image Classification competition in the beginning of 2019. Users of the Kaggle platform – an online community of data scientists and machine learners – were challenged with the task of creating algorithms capable of classifying sub-cellular proteins from fluorescence microscopy images. […]

2019-12-03, NEWS

Brodin and Elsässer announced new Wallenberg Academy Fellows

SciLifeLab researchers Petter Brodin and Simon Elsässer (Karolinska Institutet) has, together with 27 other scientists, been announced new Wallenberg Academy Fellows. The five-year grant provides young researchers with the opportunity to make important scientific breakthroughs during the time frame. Brodin (How does the environment influence infants’ immune systems?) and Elsässer (How are genetic switches inherited?) […]

2019-12-03, NEWS

Activation mechanism of the HCN ion channel revealed

Researchers from SciLifeLab have revealed the activation mechanism of the HCN ion channel by computer simulations, which was also later confirmed in the lab. HCN belongs to an important class of ion channels involved in heartbeat regulation and plays a crucial role in neurons. Most voltage-gated ion channels are opened by depolarization – which is […]

2019-12-02, NEWS

Germline specific chromosome sheds light on songbird evolution

In an international collaboration, led by SciLifeLab researcher Alexander Suh (Uppsala University), researchers have sequenced a germline-restricted chromosome (GRC) – a chromosome only found in germline cells. The GRC, found in zebra finches, turned out to be millions of years old and plays a key role in songbird biology. To an evolutionary biologist the evolution […]

2019-12-02, NEWS

DuMPLING speeds up genetic library analysis

SciLifeLab researchers have developed a new method that makes it possible to study entire cell libraries in a single experiment. By using the new method, the researchers were able to paint a clearer picture of the elusive cell cycle control mechanism in bacteria. The famous CRISPR/Cas9 system, capable of altering the expression of virtually any […]

2019-11-28, NEWS

Whole-genome sequencing reveals new, more specific biomarkers 

Researchers from SciLifeLab demonstrate that the increased precision of whole-genome sequencing can improve our understanding of how to use protein biomarkers – specific proteins circulating our blood stream – to identify biological processes connected to disease. In a recent study, led by Åsa Johansson (SciLifeLab/Uppsala University), researchers investigated protein biomarkers, that increases or decreases with […]

2019-11-26, PRESS

Press release: The Human Secretome defined – a novel map of all proteins actively secreted to blood

[Stockholm, November 26, 2019] – Today, a novel map of all proteins secreted to human blood is described. The paper by Uhlen et al. entitled “The Human Secretome” is published in the journal Science Signaling and provides a first comprehensive annotation of all proteins secreted by the human cells. In addition, an analysis of the […]

2019-11-22, NEWS

High-flying Zibo Chen awarded for engineered proteins

Flight enthusiast Zibo Chen (California Institute of Technology) is awarded the Science & SciLifeLab Prize for his designed proteins, but is nowhere close to stopping there – the goal is to customize every single component of life. Engineering cells to perform tasks can be used in biotechnology and medicine, by for example engineering bacteria to […]

2019-11-22, NEWS

Humsa Venkatesh is awarded for pushing cancer research boundaries

Humsa Venkatesh (Stanford University) is awarded the Science & SciLifeLab Prize for her research on the electrical properties of cancer cells – now she hopes to bring young researchers into this novel field. The endeavour of understanding the role of the nervous system in cancer development has only just begun. To date, research has focused […]

2019-11-22, NEWS

Barbara Klump awarded for animal behavior research

Science and SciLifeLab Prize for Young Scientists’ Ecology and Environment category winner Barbara Klump (Max Planck Institute of Animal Behavior) explores environmental factors’ influence on animal behavior, and like the New Caledonian crow, she uses hooks of her own when stepping out of the office. Barbara Klump, PhD at the University of St. Andrews and […]

2019-11-22, NEWS

Design buff Longzhi Tan awarded the Grand Prize for chromatin research

When Longzhi Tan (Stanford University) does not increase the resolution of viewing chromatin within cell nuclei, for which he is now awarded the Grand Prize of the Science & SciLifeLab Prize for Young Scientists, he designs everything from music videos to holiday cards. The Hi-C method analyzes the spatial distribution of chromatin within a cell […]

2019-11-22, NEWS

Research Reveals Three-Dimensional Genome Structure of a Single Cell

At a time when senior and well-known researchers are celebrated at this year’s Nobel Prize award, SciLifeLab, together with the internationally renowned journal Science, chooses to globally highlight and encourage prominent young life science researchers. In the second week of December, it is time for the annual Science & SciLifeLab Prize for Young Scientists to […]

2019-11-22, PRESS

Pressmeddelande: Forskning avslöjar den tredimensionella genstrukturen hos enskilda celler

I en tid då många riktar sina blickar mot årets nobelprisutdelning och hyllandet av seniora och välkända forskare väljer SciLifeLab att, tillsammans med den internationellt välkända tidskriften Science, globalt uppmärksamma framstående unga life science-forskare i början av deras karriärer. Under den andra veckan i december är det dags för utmärkelsen Science & SciLifeLab Prize for […]

2019-11-21, NEWS

Loss of the Y-chromosome leads to genetic instability

In an international collaboration published in Nature, SciLifeLab researchers have demonstrated that the loss of the Y-chromosome in blood can lead to an increased risk of cancer in other parts of the body. For this reason, the Y-chromosome can be used as an indicator for genetic instability.  It is generally known that men have one […]

2019-11-19, NEWS

New technique enables fine mapping of closely related cells in situ

SciLifeLab researchers have developed a new technique called “Probabilistic cell typing by in situ sequencing” or pciSeq. The new technique can identify cell types as well as determine their spatial location in a much more efficient way than previous methods. The global project “Human cell Atlas” has reached a point where it is now possible […]

2019-11-19, NEWS

Structure of a mitochondrial ATP synthase

SciLifeLab researchers Alexander Mühleip (Stockholm University) and Alexey Amunts (Stockholm University) solved the structure of a mitochondrial ATP synthase with native lipids. ATP synthase is a universal molecular machine for energy conversion. By coupling to cellular respiration in mitochondria, it catalyzes conversion of chemical energy of cells. Mitochondrial ATP synthase is composed of dimers that, when […]

2019-11-13, NEWS

New genetic analysis tools improve diagnosis of intellectual disability

Enabled by the SciLifeLab Clinical Genomics facility, researchers have developed new whole-genome sequencing analytical tools capable of diagnosing intellectual disabilities more accurately than previous methods. The new tools will now be introduced for first-line clinical diagnosis at the Karolinska University Laboratory. “Recent technical leaps in genetic diagnostics have revealed many new genetic aberrations that cause […]

2019-11-13, NEWS

Amunts and Brodin selected as EMBO Young Investigators

SciLifeLab scientists, Alexey Amunts (Stockholm University), Coordinating PI of the SciLifeLab Research Community Program Biology of Molecular Interactions, and Petter Brodin (Karolinska Institutet), head of the SciLifeLab Mass Cytometry facility, have been selected as EMBO Young Investigators. The prestigious four-year program identifies some of Europe’s promising young researchers and provides academic, practical and financial support to […]

2019-11-11, NEWS

Designer enzymes for degradation of synthetic plastics 

SciLifeLab researchers have developed new designer enzymes capable of breaking down synthetic plastic oligomers with tough backbones. This is a huge first step in dealing with the 7.5 billion tons of plastic that still remains unrecycled.   The plastic problem has emerged as one of the most pressing challenges that our society is facing today. For […]

2019-11-07, NEWS

Robotic production of 3D microtissue for screening and precision medicine

Scientists at SciLifeLab are using robots to produce thousands of 3D microtissues, also known as cell spheroids – in tiny droplets containing a fixed number of cells – to test drug candidates or personalized drug combinations in miniaturized versions of the targeted human tissue. Microtissue testing could also reduce the need for animal testing in […]

2019-11-06, NEWS

SciLifeLab management visits Chalmers University of Technology

On November 5, the SciLifeLab management visited Chalmers University of Technology as part of a larger tour, where the SciLifeLab management group will meet with non-host universities. The visit started off with a meeting with the Chalmers leadership which was followed by a meeting with facilities and scientists in the bioinformatics and metabolomics fields. During the […]

2019-11-06, NEWS

Researching microbial interactions against all odds – meet Sarahi Garcia

Despite growing up in one of the least advantageous places for pursuing a research career, Sarahi Garcia has gone from a path of religious mission, with no scientific aspirations, to becoming a SciLifeLab Fellow with the goal of solving environmental problems. A lot of bacteria cannot biosynthesize everything they need, or detoxify their environment from […]

2019-11-04, NEWS

SciLifeLab Cryo-EM training project travels to South Korea

Within the frame of joint development of bilateral projects between Sweden and South Korea, SciLifeLab scientists from the labs of Alexey Amunts and Erik Lindahl, as well as the cryo-EM facility, trained over 200 students and postdocs in four Universities in South Korea.  The training workshops included 40 hours of lectures and practical work in […]

2019-10-30, NEWS

Shedding light on the Bantu migration

Facilitated by the SciLifeLab NGI, researchers from Portugal, Sweden, Germany and Mozambique discovered the first genetic evidence of a rapid north-south dispersal of Bantu people along the Indian Ocean Coast, which was earlier suggested based on the geographic location of previous archaeological findings. The Bantu expansion started in west central Africa around 5,000 years ago […]

2019-10-29, NEWS

SciLifeLab proposal to research bill: frontline research infrastructure is critical to make Swedish life science world-leading

Sweden has significant potential to fulfill the government’s ambitions of becoming a leading life science nation. However, in light of global competition and massive life science investments being made abroad, it is critical that Swedish researchers have access to the latest infrastructure needed to perform cutting-edge research. The ambitions of the national life science strategy […]

2019-10-28, NEWS

Earliest known tetrapod probably never left the water

An international team, led by Per Ahlberg (SciLifeLab/UU), has found evidence suggesting that the earliest tetrapods – the group of animals that made the evolutionary transition from water to land – might never have left the water. The first tetrapods evolved from fish and lived between 360-390 million years ago during the Devonian period. So […]

2019-10-22, NEWS

New method facilitates identification of aggressive tumors

Researchers at SciLifeLab have developed a new, more cost efficient, method that can be used to identify heterogeneous tumors which are often more aggressive and requires a more specialized treatment. Existing strategies for massive parallel sequencing of genomic DNA relies heavily on library indexing, a process where DNA samples are tagged with index sequences allowing […]

2019-10-18, NEWS

Sweden joins the Earth Biogenome Project through SciLifeLab

SciLifeLab researchers and the Genomics platform at SciLifeLab now announce that they will contribute with their expertise and technologies to the global Earth Biogenome Project, analyzing the genetic makeup of more than one million species.   Our knowledge about the genetic composition of life is limited to less than 0.2% of the species inhabiting our […]

2019-10-18, PRESS

Pressmeddelande: Sverige ansluter sig till Earth Biogenome-projektet

Genom SciLifeLab har nu även Sverige tagit steget till att bidra med expertis och teknologi inom det världsomspännande initiativet Earth Biogenome Project, där arvsmassan för över en miljon arter bestäms.  Tills relativt nyligen var det ett tidskrävande och dyrt åtagande att kartlägga en enskild arts arvsmassa, men under det senaste decenniet har kapaciteten för storskalig […]

2019-10-17, NEWS

SciLifeLab Fellows awarded 28,000,000 SEK from KAW

SciLifeLab Fellows Jens Carlsson and Lucie Delemotte have been awarded 28,000,000 SEK to identify differences and similarities between specific receptors, which in the long term could lead to the development of new drugs that are more precise and has less side effects. “When we know how these molecular machines work at the atomic level, we will be […]

2019-10-17, NEWS

Angiogenesis mechanism revealed

Researchers from SciLifeLab and Uppsala University have discovered a mechanism for angiogenesis, which is the formation of new blood vessels, and have demonstrated the importance of the mechanism in organ development and embryonic survival. The findings might be of importance when trying to control angiogenesis in different diseases such as cancer. In the recent study, […]

2019-10-15, NEWS

Complex diseases initiative facilitated by SciLifeLab RCP

Genomic Medicine Sweden (GMS) and the Genomic Aggregation Project in Sweden (GAPS) was earlier brought together by the SciLifeLab research community program “Large-scale clinical genomics and complex diseases”. Now, the collaboration has led to yet another focus area within GMS, regarding “complex diseases” –  diseases where multiple genes, lifestyle and environmental factors all contribute to the […]

2019-10-09, NEWS

Receptor modifying proteins thought to be behind mysterious drug failures

Researchers from SciLifeLab and the Rockefeller University (New York) have presented a new method for studying the “interactome” of G protein-coupled receptors (GPCRs) and Receptor activity-modifying proteins (RAMPs). GPCRs are a very important class of cell receptors involved in everything from vision and taste to hormonal regulation and neuronal communication. Intracellular signalling is activated by […]

2019-10-08, NEWS

Multiple neurotransmitters mapped in a single experiment

Researchers, led by Per Andrén (SciLifeLab/UU) have developed a new mass spectroscopy imaging (MSI) approach for creating comprehensive neurotransmitter network maps of specific brain regions. The new approach makes it possible to visualize large number of signal substances simultaneously, something that hasn’t been possible before, and is applicable on both thin tissue and liquid samples […]

2019-10-02, NEWS

Understanding naïve pluripotent stem cells

In a recent study, led by ScilifeLab Fellow Simon Elsässer and PhD Student Banushree Kumar, researchers investigate the mechanism responsible for stabilizing mouse naïve pluripotent stem cells, cells that can divide into all other cells types, in mice. Embryonic stem cells are formed during the earliest stages of life and will later on give rise […]

2019-09-27, NEWS

SciLifeLab inspires new generation of scientists

As part of the annual event Researchers’ Night (ForskarFredag), SciLifeLab in Stockholm welcomed high school students from six high schools on September 27. ForskarFredag is part of European Researchers’ Nights, an initiative that aims to bring researchers closer to the public. Another goal is to motivate young people to embark on research careers. Scientists from […]

2019-09-26, NEWS

Ancient DNA facility kickstarts with symposium

The SciLifeLab Ancient DNA facility is now up, running and taking on projects. To celebrate this and inform users of the possibilities of using the facility, a symposium was held September 24-25. In short, ancient DNA analysis provides insight into traits, ancestry, and migration of humans, animals and plants. “Ancient DNA is a time capsule […]

2019-09-25, NEWS

Anna Wedell is awarded the 2019 Forska!Sverige science award

The Swedish foundation Forska!Sverige is awarding Anna Wedell (SciLifeLab/KI) with its Research Award 2019. The professor of Medical Genetics wins the award based on her research accomplishments regarding detection of congenital and hereditary metabolic disorders in children. She will receive the award in conjunction with the Forska!Sverige-day on October 2nd. Today, around one in every two thousand […]

2019-09-24, NEWS

SciLifeLab National hearing

Since its launch in 2010, SciLifeLab has contributed to some of Sweden’s most successful research endeavors, enabled recruitment of outstanding international researchers and created a unique environment for cross-sector collaborations. Going into its second decade, SciLifeLab is focused on the challenges of tomorrow’s research and society. How should SciLifeLab develop as a national research infrastructure? […]

2019-09-24, NEWS

SciLifeLab postdocs and facility directors exchange ideas

Last week, 21 postdocs and four facility directors met in Uppsala to present their work and were given an opportunity to interact with each other during the event Pushing the Frontiers. The Scientific Director of SciLifeLab in Uppsala, Mia Phillipson, and the SciLifeLab committee at Uppsala University set the stage for the heads of the […]

2019-09-19, NEWS

New method could improve breast cancer diagnostics

A new methodological approach, developed by researchers from SciLifeLab, could help improve breast cancer diagnostics and provide insight in the hunt for new therapeutic targets. The study was published in EBioMedicine. Today, breast cancer analysis relies on homogenized tissue samples, something that does not provide accurate information about signaling mechanisms or cellular interactions due to […]

2019-09-18, NEWS

Better resolution and AI can detect single tumor cells

Researchers from SciLifeLab, KTH, MIT and Harvard have developed a new method relying on artificial intelligence that can identify single tumor cells in high resolution images. The study was published in Nature Methods. The location and genetic setup of cells determines tissue function but so far no methods to capture both at the same time […]

2019-09-12, NEWS

Nominate your favorite speaker!

Who is the speaker of your dreams? The two SciLifeLab Seminar Series (SciLifeLab The Svedberg Seminar Series in Uppsala and SciLifeLab Seminar Series-Campus Solna in Stockholm) are now open for new nominations. If you could invite any researcher you wanted, from any part of the world, and have someone else pay for all associated costs, […]

2019-09-11, NEWS

Visceral fat in women more strongly linked to diseases

In a recent study, led by Åsa Johansson (SciLifeLab/Uppsala University), researchers investigated the relationship between visceral fat – fat surrounding organs and the intestines – and an increased risk of developing diabetes, heart attacks, hypertension and hyperlipidemia.  The comprehensive study, with over 325,000 participants, confirmed that visceral fat fat is a major risk factor for […]

2019-09-11, NEWS

International prize to SciLifeLab facility director Gunnar von Heijne

SciLifeLab Cryo-EM director Gunnar von Heijne (Stockholm University) have been awarded The Biophysical Society’s 2020 Anatrace Membrane Protein Award. Gunnar von Heijne, Professor of theoretical Chemistry at the Department of Biochemistry and Biophysics at Stockholm University, receives the award based on his profound contributions in creating important theoretical and experimental tools that increase the understanding of the […]

2019-09-10, NEWS

120 researchers attended 3-day SciLifeLab RCP symposium

To facilitate internationally competitive, cutting-edge collaborative research across Sweden, SciLifeLab supports seven Research Community Programs (RCPs) – networks that connect researchers with each other and with the SciLifeLab infrastructure. On August 26-28 a 3-day RCP symposium ‘The Dynamics of Life’ took place at Djurönäset (Stockholm) and more than 120 researchers from 13 institutions attended the event. The symposium […]

2019-09-06, NEWS

Unique blood, brain and metabolism protein atlases launched

        Three new databases describing all proteins within human metabolism, blood and brain are now launched as part of The Human Protein Atlas – a SciLifeLab Research Community Program. The new open access atlases provide unique resources for the study of human biology and for researchers developing new treatments. Yesterday, on September 5, The […]

2019-09-05, PRESS

[Pressmeddelande] En atlas över människans hjärna och blod

Teamet bakom det svenska forskningsprojektet Human Protein Atlas lanserar idag övergripande karaktäriseringar av alla proteiner som förekommer i människans blodceller, olika delar av hjärnan och kroppens ämnesomsättning. Dessa tre nya delar har i syfte att öka förståelsen för människans molekylära byggstenar och att underlätta tillämpad forskning som syftar till bättre och effektivare medicinsk behandling i framtiden.

2019-09-05, NEWS

Cyanobacterium re-engineered to produce 1-butanol from CO2

Researchers from Uppsala University have successfully re-engineered Cyanobacterium Synechocystis PCC 6803 to effectively produce 1-butanol and other chemicals from water and CO2. Cyanobacteria can be engineered to directly convert CO2 and water into biofuel and chemicals through photosynthesis. The efficiency and speed of the synthesis is still too low for industrial use, however.  In the […]

2019-09-05, NEWS

Effect of linked selection on genetic variation in plants

In a recent study, published in Ecology and evolution, researchers from SciLifeLab investigated the effect of linked selection on genetic diversity in two plant species, Arabidopsis lyrata and Capsella grandiflora. The results could help scientists understand the forces that shape genetic variation in natural populations. Mutations, genetic drift – random loss of alleles in small […]

2019-09-02, NEWS

New group of students to unique master’s program

Today, SciLifeLab welcomes new students to the master’s program Molecular Techniques in Life Science, a unique collaboration between Karolinska Institutet, KTH Royal Institute of Technology and Stockholm University. The program is to a large extent held at SciLifeLab in Solna. The two-year master’s program prepares students for a professional research career in life science, with […]

2019-08-29, NEWS

Shedding light on bacterial filamentation 

  In a recent study a group led by SciLifeLab Fellow Kristina Jonas (Stockholm University) sheds light on the molecular mechanisms and ecological relevance behind filamentation in the freshwater bacterium, Caulobacter crescentus. Bacteria are often depicted as rod or coccus shaped cells but come in a large variety of shapes and forms in nature. Many of […]

2019-08-28, NEWS

New technique for using exosomes as biomarkers 

There is a growing demand for biomarkers that can help detect diseases like cancer or neurodegenerative diseases at an early stage, as well as for follow-up treatments. Exosomes, a subclass of  membrane coated vesicles released from the cell through exocytosis, could be the next big step in the hunt.  Exosomes are important in a number […]

2019-08-28, NEWS

Protection against harmful mutations found in mushrooms 

According to a new study, facilitated by SciLifeLab’s National Genomics Infrastructure (NGI), certain mushroom species seem to accumulate surprisingly few mutations over time. This suggests a well developed protection against harmful mutations and the results could be important for future drug development.   In the study, published in the journal Current Biology, researchers from Uppsala University […]

2019-08-22, NEWS

Jennifer Doudna visits SciLifeLab

Today, biochemistry Professor Jennifer Doudna (UC Berkeley, USA) met with PhD-students and postdocs at SciLifeLab prior to speaking at the annual lecture in Structural Biology. Doudna’s lab is mostly known for their work on re-engineering the CRISPR–Cas9 system to provide an effective tool for gene editing.  The CRISPR-Cas9 system is originally an antiviral defense system found in prokaryotes. CRISPR […]

2019-08-22, NEWS

Bacteria translates blocked mRNA by using standby site

Bacterial ribosomes bind to mRNA on a specific binding site called ribosomal binding site (RBS). This process requires single stranded RNA since the structure of stable RNA blocks initiation. So how come stable mRNA is still translated in bacteria? To answer this, scientists from Uppsala University, among them SciLifeLab Fellow Sebastian Deindl, used an old hypothesis […]

2019-08-21, NEWS

SciLifeLab researcher Sten Linnarsson awarded SEK ten million for brain development research

Sten Linnarsson, researcher at SciLifeLab and professor of molecular systems biology at Karolinska Institutet, is studying the development of the human brain. Now, the Royal Swedish Academy of Sciences is awarding him this year’s Torsten Söderberg Academy Professorial Chair in Medicine for his work on establishing a detailed map of the human brain. The grant […]

2019-08-14, NEWS

Same genes affect the risk of asthma, hay fever and eczema

SciLifeLab researchers have identified 141 genes associated with an increased risk of developing asthma, hay fever and eczema. 41 of the identified genes have not previously been linked to either of the diseases and the result was published in the scientific journal Human Molecular Genetics. Diseases like asthma, hay fever and eczema are not caused […]

2019-08-05, NEWS

SciLifeLab, Stockholm University and AstraZeneca use cryo-EM to advance biomedicine

SciLifeLab Fellow Alexey Amunts and his team in collaboration with AstraZeneca unravel the molecular details of the extracellular region of the receptor tyrosine kinase RET involved in cell signalling.  The study published in Science Advances reveals the mechanism by which the receptor tyrosine kinase RET can increase neuronal survival in degenerative diseases. To understand the mechanism of this signalling […]

2019-07-26, NEWS

Miniaturized ribosome found in microsporidia

In a recent study, co-led by SciLifeLab National Fellow Jonas Barandun (SciLifeLab/Umeå University), researchers presented near atomic details of the smallest known eukaryotic protein synthesis machine, the microsporidian ribosome. The study was published in Nature Microbiology. Microsporidia, a group of unicellular spore-forming fungi, known to parasitize almost every animal and with at least 14 different […]

2019-07-19, NEWS

New biomarker panel for diagnosis of chronic periodontitis

Facilitated by the ScilifeLab NGI, researchers from Karolinska Institutet, SciLifeLab and KTH have created a new biomarker panel for diagnosis of chronic periodontitis by sequencing salivary samples and mapping inflammatory mediators from affected patients. Periodontitis is a common chronic inflammatory disease affecting the teeth and gums. Except leading to tooth loss it can also contribute […]

2019-07-05, NEWS

Mia Phillipson appointed new SciLifeLab Scientific Director

The SciLifeLab Board appoints physiology professor Mia Phillipson as Scientific Director, representing Uppsala University, in the SciLifeLab Management Group. Mia Phillipson is a professor in physiology since 2014 at Uppsala University. She is a member of the SciLifeLab faculty and her current research focuses on immune cell recruitment to sites of inflammation or injury, the role […]

2019-06-27, NEWS

Evolution of gene expression in the world’s most common weed

In a recent study led by Martin Lascoux (SciLifeLab/UU) researchers investigated the evolution of gene expression in the world’s most common weed, the shepherd’s purse (Capsella bursa-pastoris). Polyploidy, or whole genome duplication, is a major evolutionary mechanism and most animal and plant species have a polyploid at some point of their ancestry.  The shepherd’s purse, […]

2019-06-27, NEWS

Ilaria Testa aims to observe every molecule

She developed a microscope that cut the time of imaging a living cell with molecular resolution from about forty minutes to half a second. Now Ilaria Testa wants to shed light on neuronal processes by observing morphology that no one has ever seen before. Ilaria Testa works, as she puts it, “at the interface between physics […]

2019-06-27, NEWS

Six joint molecular medicine projects as Fellows from SciLifeLab and WCM(T)M team up

  The National Molecular Medicine Fellows Program (NMMP) has announced the initiatives approved for this year’s Scientific Network Facilitation Grant for SciLifeLab members. Six of the seven funded projects are novel research collaborations between SciLifeLab Fellows and Fellows from the Wallenberg Centres for Molecular Medicine (WCMM and WCMTM) in Gothenburg, Linköping, Lund and Umeå.   […]

2019-06-26, NEWS

Eight Postdoc projects funded to stimulate collaboration

Eight Postdoc projects will receive funding from the SciLifeLab committee at Stockholm University. The aim of the initiative is to stimulate collaborations between principal investigators at SciLifeLab and other parts of the Stockholm University campus as well as between research groups from different disciplines. Each funded project has a main applicant from Stockholm University, and one […]

2019-06-24, NEWS

New blood test makes it easier to diagnose ovarian cancer

In a recent study, led by Ulf Gyllensten (SciLifeLab / Uppsala University), researchers from Uppsala University and the University of Gothenburg, developed a new blood test that can distinguish between malignant and benign ovarian tumors in order to avoid unnecessary and risky surgery in women with suspected cancer. Ovarian cancer is often discovered late and […]

2019-06-19, NEWS

The Anders Jahre Senior Medical Prize goes to Carl-Henrik Heldin

The Anders Jahre Senior Medical Prize goes to SciLifeLab researcher, and chairman of the SciLifeLab board, Carl-Henrik Heldin (Uppsala University), for his groundbreaking research about growth factors and cancer. The prize rewards outstanding research done in the fields of basic and clinical medicine and is awarded by the University of Oslo. It is one of the biggest […]

2019-06-18, NEWS

Droplet digital PCR suitable for gene copy number determination

In a recent study, SciLifeLab researcher Dan Larhammar (Uppsala University) and his group investigates new, more accurate, ways to determine gene copy number variation.  Copy number variation (CNV), a process where part of the genome is repeated two or more times. Sometimes whole genes are copied and the amount of repeats varies between individuals in […]

2019-06-17, NEWS

The Svedbergspriset 2019 goes to SciLifeLab Fellow Magda Bienko

SciLifeLab Fellow Magda Bienko (Karolinska Institutet) has been awarded the Svedbergpriset 2019 for her research about DNA-organization and how it affects gene expression in different cell types. In order to to better understand the molecular mechanism behind this Magda had to develop several tools during her research. One of those is the new sequencing method […]

2019-06-12, NEWS

Review and recommendations by the SciLifeLab International Advisory Board

The report is in. Following their review of and visit to SciLifeLab earlier this spring, the SciLifeLab International Advisory Board (IAB) has now released a comprehensive evaluation document summarizing their view on our center. This 3rd IAB visit was the first of its kind in that it covered the entire SciLifeLab community and all stakeholders. […]

2019-06-11, NEWS

First European biobank for research on drugs in breast milk

In a new European research project known as Conception, scientists will evaluate how drug treatment affects pregnant and breastfeeding women. Uppsala Biobank, will begin collecting breast milk and blood samples from pregnant and lactating women currently on drug treatment. In addition, the SciLifeLab Drug Optimization and Pharmaceutical Profiling facility (UDOPP) will develop new methods to analyze the […]

2019-06-05, NEWS

One step closer to understanding tonic immobility

Certain animal behaviors can be explained by genetic factors but finding out the molecular mechanisms behind them is a lot more difficult. Understanding them can lead to knowledge about how behavior is controlled by genes, however. In a recent study enabled by the SciLifeLab NGI, researchers from Linköping University, Swedish University of Agricultural Sciences and the […]

2019-05-29, NEWS

Shedding light on Salmonella host cell invasion mechanisms

SciLifeLab Fellow Mikael Sellin (Uppsala University) and his team shed light on the Salmonella host cell invasion mechanisms by using chromosomally tagged strains. Salmonella enterica serovar Typhimurium (S.Tm), a common and widespread bacterium, invades epithelial cells in the gut mucosa and later on, during the infection, also a variety of immune cells. S. Tm gains […]

2019-05-29, NEWS

Mark Dopson’s mining waste cleanse

The mining industry is often considered a dirty business. The environmental impact is severe to say the least. But can research mitigate the negative effects? Mark Dopson is investigating precisely this, and generates some electricity while doing it. “Clouds of sulfides solidify into towering chimneys as tall as a three-story house. At four hundred degrees […]

2019-05-28, NEWS

SciLifeLab brings research to school

Sometimes cutting edge technology, found in SciLifeLab’s laboratories, is far away from high school classrooms. That is why Björn Einarsson, a science teacher from “Kungsholmens västra gymnasium”, decided to visit SciLifeLab and Janne Lehtiö’s group. He wanted to learn more about biotechnology and possibly find a way to bring some of it back to his […]

2019-05-27, NEWS

Petter Brodin new member of the Young Academy of Sweden

Eight prominent scientists have been elected new members of the Young Academy of Sweden. One of them is Petter Brodin, associate Professor and Facility Director of the SciLifeLab Mass Cytometry facility. ”I am honored by this recognition of the work me and my team has been doing, and I aim to use this platform to […]

2019-05-23, NEWS

PhD Council brings researchers of different disciplines together

At May 23, the SciLifeLab PhD Council held a symposium at Karolinska Institutet titled Building up upon blocks of knowledge. The building blocks consisted of six scientific fields the PhD Council have identified SciLifeLab being engaged in: Genomics, Synthetic Biology, Bioinformatics, Bioimaging & Molecular Structure, Drug Discovery and Proteomics. “We hope to build a bridge […]

2019-05-23, NEWS

Three new Clinical Genomics nodes

The Clinical Genomics facilities merged and became the Clinical Genomics Infrastructure May 1, 2019, adding three new nodes in addition to the previous four facility locations. The facility will have seven nodes spread across Sweden, of which three are at new locations: Linköping, Umeå and Örebro. The Clinical Genomics Infrastructure is part of the national […]

2019-05-21, NEWS

Help us shape the future range of SciLifeLab services

SciLifeLab always seeks to provide you, the research community, with access to the latest and greatest of advanced instrumentation and related expertise. We would therefore like to tap into your ideas on which services are most urgently needed to take your own research to the next level and keep Sweden at the cutting edge in […]

2019-05-20, NEWS

Dog ownership is influenced by hereditary factors

According to a new study, co-led by Tove Fall (SciLifeLab/Uppsala University), your genetic make-up greatly influence your decision to own a dog. By studying data from 35 035 twin pairs from the Swedish Twin Registry, the researchers observed that it was far more common for identical twin siblings to both own a dog than non-identical twin […]

2019-05-17, NEWS

All about Artificial Intelligence at Science Summit 2019

On May 15, over 300 participants attended the SciLifeLab Science Summit 2019 at Uppsala Konsert & Kongress. This year’s topic was Artificial Intelligence in Life Sciences and the conference highlighted both the progress already attained by using AI, and the opportunities and risks of future developments. After a few welcoming words from Olli Kallioniemi (SciLifeLab […]

2019-05-15, NEWS

10,000-year-old chewing gums uncover ancient Scandinavians’ DNA

Using the SciLifeLab National Genomics Infrastructure (NGI), a study led by Anders Götherström from Stockholm University has successfully extracted and sequenced genetic material from ancient chewing gums of birch bark pitch found on the Swedish west coast. The results reveal that the DNA came from three separate individuals living in the area around 10,000 years […]

2019-05-14, NEWS

Immune response in tuberculosis mapped

Facilitated by our recently started In situ sequencing facility at SciLifeLab, researchers were able to generate a detailed map of tuberculosis immune response in mice lungs. The findings contribute to the understanding of the disease as well as speeding up the development of new vaccine candidates. Tuberculosis is a disease caused by a bacterium called […]

2019-05-10, NEWS

Scientists discuss functional precision cancer medicine at SciLifeLab

At may 10, SciLifeLab hosted a mini-symposium in its facilities in Solna aiming to bring together scientists interested in the field of functional precision cancer medicine. Functional precision cancer medicine combines the objective of matching the right drugs to the right patients in precision medicine with a broadened toolkit of functional information. “This mini-symposium provides […]

2019-05-09, NEWS

Shedding light on mitochondria scaffolding proteins

Facilitated by SciLifeLab Advanced Light Microscopy facility (ALM), researchers from the Max Planck Institute for Biophysical Chemistry in Germany uncovered important information about the architecture of the mitochondrial inner membrane. Mitochondria are double-membrane organelles working as cellular power plants and essential for all eukaryotic life. Their inner membranes are intricately folded so that the surface […]

2019-05-08, NEWS

Frances Arnold creates new protein catalysts

Frances Arnold, Professor of Chemical Engineering, Bioengineering and Biochemistry at the California Institute of Technology, was awarded the Nobel Prize in Chemistry in 2018 for her work in directed evolution, making her the first American woman to ever win the prestigious prize. On May 8, she visited SciLifeLab to hold the seminar: Innovation by Evolution: […]

2019-05-06, NEWS

Matilda Ernkrans visits SciLifeLab

On May 2, Matilda Ernkrans, Minister for Higher Education and Research, visited SciLifeLab. Olli Kallioniemi, Director of SciLifeLab, co-hosted the visit together with Sigbritt Karlsson, President of KTH and Ole Petter Ottersen, President of Karolinska Institutet. Sigbritt Karlsson and Ole Petter Ottersen addressed the importance of SciLifeLab and research infrastructure within the life science sector […]

2019-05-03, NEWS

Nobel Laureate Frances Arnold visits SciLifeLab on may 8

Frances Arnold, Professor of Chemical Engineering, Bioengineering and Biochemistry at the California Institute of Technology, was awarded the Nobel Prize in Chemistry in 2018 for her work in directed evolution, making her the first American woman to ever win the prestigious prize. Now she will visit SciLifeLab to hold the seminar: Innovation by Evolution: Bringing New Chemistry to […]

2019-05-02, NEWS

New method for protein analysis based “liquid biopsy”

Blood sample analysis or “liquid biopsy” is a good way to quickly get a general overview of a person’s health. Unfortunately, most methods currently available only detect blood proteins and are not sensitive enough to analyze the less abundant tissue leakage proteins, consisting of cellular proteins leaked from a large variety of tissues from all […]

2019-05-02, NEWS

Linking chromosome 22 to increased risk of bladder exstrophy

The bladder exstrophy‐epispadias complex (BEEC) is a malformation of the bladder and urethra in newborns. The underlying causes are still largely unknown but are thought to be genetic except for certain environmental factors. The most common genetic aberration is found on chromosome 22 in a location called 22q11.2. In a recent study, facilitated by the […]

2019-05-02, NEWS

Researching cells through colorful imaging

The Cell Profiling facility at SciLifeLab has a unique library of more than 25 000 validated antibodies, which are used to create strikingly colorful images describing the inner workings of cells. But how does the image creation work exactly, what does Head of Facility Charlotte Stadler see for the future of Cell Profiling and how […]

2019-04-25, NEWS

Improving protein synthesis by microfluidic screening and gene downregulation  

Protein synthesis is a biotechnical process in which selected genes are inserted into host cells, normally yeast Saccharomyces cerevisiae, that can then produce large amounts of protein. These proteins, called recombinant proteins, can then be used as medicines or enzymes. The synthesis involves a number of important steps, like the formation of proteins from amino […]

2019-04-23, NEWS

SciLifeLab researcher Sten Linnarsson chosen to be Wallenberg Scholar

SciLifeLab researcher Sten Linnarsson (Karolinska Institutet) is one of 22 researchers, among the foremost in their respective fields in Sweden, that have been chosen as this year’s Wallenberg Scholars. The scholars will receive 18 million SEK each from the Wallenberg Foundations in the form of five-year grants for “free research”. “Free research is what it […]

2019-04-17, NEWS

New study sheds light on DNA movements during nucleosome remodeling.

Our genetic material, the DNA, is packaged into a tightly condensed structure referred to as chromatin. The chromatin is in turn made up of nucleosomes which all contain a stretch of DNA wrapped around a cylinder-shaped core consisting of histone proteins. Inside the nucleosome, the DNA is largely shielded from interactions with proteins, which means […]

2019-04-16, NEWS

Combined genome and proteome level analysis reveals insights in childhood leukemia

In a recent study, led by Janne Lehtiö (SciLifeLab/Karolinska Institutet) and Kajsa Paulsson (Lund University), researchers identified molecular changes in the regulation of the chromosomal architecture in patients with acute lymphoblastic leukemia. The most common form of cancer in children is acute lymphoblastic leukemia (ALL). In Sweden alone, 65 children and teenagers are diagnosed with […]

2019-04-16, NEWS

New online resource accelerates lab technique visualizing single cell DNA

SciLifeLab Fellow Magda Bienko (KI) and Nicola Crosetto (SciLifeLab/KI) recently released a publicly available online platform called iFISH. The platform is designed to accelerate and facilitate the production of FISH-probes used in Fluorescence In Situ Hybridization (FISH), a technique for studying how the genome is spatially organized in the cell nucleus. FISH, first established in the […]

2019-04-15, NEWS

SciLifeLab Fellows receive STINT funding

Marc Friedländer, Vicent Pelechano and Claudia Kutter receives STINT funding. SciLifeLab Fellows Vicent Pelechano (Karolinska Institutet), Claudia Kutter (Karolinska Institutet) and Marc Friedländer (Stockholm University) have recently been granted funding for a research collaboration with a university in Shanghai, China. In 1994, the Swedish Foundation for International Cooperation in Research and Higher Education (STINT) was […]

2019-04-10, NEWS

Sean Rudd receives six year funding award

Sean Rudd, Assistant professor in Thomas Helleday’s research group (SciLifeLab/Karolinska Institutet), has been awarded the Junior Investigator Award from the Swedish Cancer Society – Cancerfonden. The Swedish Cancer Society funds research positions with the purpose of getting a continuity in cancer research, thereby increasing the possibility of identifying and treating cancer. Sean Rudd will be […]

2019-04-09, NEWS

Painting a molecular picture of breast cancer

In a new study, led by Janne Lehtiö (SciLifeLab/Karolinska Institutet), researchers from SciLifeLab, University of Oslo, and MD Anderson Cancer Center have generated a detailed map of protein levels in breast cancer tumors. This molecular map complements the DNA and RNA picture of breast cancer and sheds light on how different mutations give rise to […]

2019-04-09, NEWS

Closer to ALS cure with new gene expression atlas

In a novel study, published in Science and co-led by Joakim Lundeberg (SciLifeLab/KTH), an approach known as Spatial Transcriptomics was used to map gene expression of nearly 12 000 genes during early onset and progression of the neurodegenerative disease ALS. The findings will be useful in searching for a cure, better diagnostics and in creating […]

2019-04-05, NEWS

Evolution and genes of songbird sex chromosomes revealed

Birds-of-paradise, belonging to the songbird species, are well known for their diversified sexual traits such as extraordinary plumage forms and colors, sophisticated songs and mating rituals. In a collaborative study, involving the University of Vienna, the University of Zhejiang and the Swedish Museum of Natural History, genomes of 11 songbirds, including five birds-of-paradise, were analyzed […]

2019-04-03, NEWS

Side effects: To prevent or not to prevent

Mia Wadelius and Pär Hallberg, both chief physicians at Uppsala University, have spent a lifetime trying to understand side effects of drugs – with research on the swine flu vaccine Pandemrix being their most recent published work. It turns out that implementing their findings in health care is easier said than done, however. When treating […]

2019-04-02, NEWS

Per-Olof Syrén awarded for unique approach

Per-Olof Syrén (SciLifeLab/KTH) is awarded The Gunnar Sundblad Research Foundation’s Skills Development Prize of 2019, to highlight his unique approach of producing bio‐based polymers. The new field of research Per-Olof Syrén has introduced is called polymer retrobiosynthesis. This approach builds on synthetic biology, chemical retrosynthesis and polymer chemistry to enable efficient upgrading of renewable building blocks […]

2019-03-29, NEWS

First disease linked to defective myoglobin

In a recent study, published in Nature Communications and co-led by Anna Wedell (SciLifeLab/ Karolinska Institutet), researchers have discovered the underlying cause of a hereditary muscle disease first characterized in a Swedish family in 1980. It is the first time researchers have discovered a link between a disease and defective myoglobin, the protein responsible for […]

2019-03-28, NEWS

Automating multiplexed in situ sequencing by adapting existing microfluidic tool

Advancements in the automation of multiplex in situ sequencing (ISS), a technique that allows visualization of gene expression of thousands of genes in entire tissue sections, helps bringing automation of the technique closer to mainstream use. In a recent study, led by Mats Nilsson (SciLifeLab / Stockholm University), a new approach towards automated in situ […]

2019-03-28, NEWS

Selected SciLifeLab sequencing services free-of-charge through EU-funding

On February 1st, the European Advanced infraStructure for Innovative Genomics (EASI-Genomics) initiative was launched to provide free-of-charge transnational access to advanced sequencing technologies. From SciLifeLab, the National Genomics Infrastructure (KTH Royal Institute of Technology/Uppsala University) and in situ sequencing (Stockholm University) services have joined the effort. The first call for proposals, closing on April 25, […]

2019-03-25, NEWS

New dog model for studying Stargardt’s eye disease

In a recent study, published in PLOS genetics, a novel form of retinal degeneration in dogs was successfully investigated using whole genome sequencing. The study, led by scientists from the Swedish University of Agricultural Sciences, was enabled by the SciLifeLab National Genomics Infrastructure (NGI) and National Bioinformatics Infrastructure (NBIS). Stargardt disease (STDG) is an autosomal […]

2019-03-21, NEWS

Visit from the SciLifeLab International Advisory Board (IAB)

On March 13 to 15, SciLifeLab’s International Advisory Board visited SciLifeLab for the third time. The board visited SciLifeLab’s venues in both Stockholm and Uppsala to evaluate the operations and give advice on how we can develop even further.

2019-03-21, NEWS

Marc Friedländer traces origins through microRNA

The number-loving computational biologist and smørrebrød master Marc Friedländer and his research group has recently discovered a way to tell what species tissue samples come from, by using microRNAs. Now they set out to revolutionize the field. Marc Friedländer is a computational biologist and thereby spends most of his days at his computer. When asked […]

2019-03-19, NEWS

Premature children show adequate amount of maternal antibodies

In human newborns IgG antibody production starts 15 weeks after birth rendering them completely dependent on maternal antibodies transferred across the placenta during pregnancy, a phenomenon known as passive immunity. The concentration of maternal IgG in the fetus increases dramatically during the third trimester which has led to the belief that prematurely born children mostly […]

2019-03-11, NEWS

Genetic testing of colorectal cancer of low value before the age of 40

A study published in Molecular Genetics & Genomic Medicine concludes that the chance of detecting a hereditary cancer syndrome in young colorectal cancer patients is low. The study was enabled by the SciLifeLab National Genomics Infrastructure (NGI). Colorectal cancer is the third most common cancer diagnosed in Sweden. Development of the disease before the age […]

2019-03-05, NEWS

SciLifeLab-AstraZeneca collaboration maps gene expression in heart failure

In the SciLifeLab/AstraZeneca collaboration on heart failure, a study has been published in Scientific Reports ( on mRNA expression in myocardial biopsies, obtained from patients undergoing elective coronary bypass surgery, as part of the large study named PREFERS (Preserved and Reduced Ejection Fraction Epidemiological Regional Study). The study was led by SciLifeLab researcher Bengt Persson […]

2019-03-04, NEWS

Few genes involved in the wall lizard’s different traits

Different colored lizards of the same species differ in size, fighting ability and reproductive strategies – due to variation in only two genes, shows a study led by researchers from Uppsala University and the University of Porto. The study was enabled by the SciLifeLab National Genomics Infrastructure (NGI). Reptiles show a diverse range of colors […]

2019-02-28, NEWS

New findings could help children with growth disorders

Researchers at Karolinska Institutet have discovered that bone growth in mice functions the same way new cells are being produced in blood, skin and other tissue – not a fixed number of “growing cells” that run out and we stop growing, as previously thought. The study was enabled by the SciLifeLab National Genomics Infrastructure (NGI). […]

2019-02-27, NEWS

Portal to help interpret cancer data developed – first patients selected

The first patients have been selected for precision cancer therapy using the Molecular Tumor Board portal, a platform to support clinical decisions based on the genomics profile of the tumors. The Molecular Tumor Board portal is developed by researchers at Karolinska Institutet and SciLifeLab to help clinicians interpret biological cancer data and select the most […]

2019-02-26, NEWS

New skeletal disease uncovered

A group of researchers led by physician and Associate Professor Giedre Grigelioniene (Karolinska Institutet) have identified a previously unknown skeletal dysplasia. The study, now published in Nature Medicine, describes the molecular mechanism behind this rare condition. Their analyses were enabled by a SciLifeLab Clinical Genomics facility. A mother and her child had come to the clinic […]

2019-02-25, NEWS

More paternally expressed genes than previously thought

A recent study, published in Genome Biology, shows that there are substantially more paternally expressed genes in the endosperm of the plant Arabidopsis than what has previously been identified. This indicates that paternal-specific gene expression is of higher functional relevance than previous estimates. Genomic imprinting is an epigenetic phenomenon causing maternal and paternal alleles to […]

2019-02-22, NEWS

Evolution of common weed depends on parental legacy

A recent study led by Martin Lascoux (SciLifeLab/Uppsala University) shows how the evolutionary trajectory of a newly formed tetraploid species of plant closely depends on its parental legacy and on DNA presence from its diploid relatives. Most plant species have a polyploid origin, and many of them are allopolyploid species, which means that they originated […]

2019-02-18, NEWS

Less snow may hasten climate change

According to a new study, published in mSphere and led by SciLifeLab Fellow Sari Peura, a decreased snow cover on lakes increase the levels of methane, something that may hasten climate change. Climate change may lead to less snow covering lakes in boreal and subarctic regions. Forest lakes are substantial contributors of methane emissions, and research […]

2019-02-18, NEWS

Absent protein potential target for diabetes drug treatment

Knowledge of a newly discovered genetic disorder can lead way to development of new diabetes drugs. This is shown in a study co-led by SciLifeLab researcher Anna Wedell (Karolinska Institute) and published in the journal Diabetes. The newly discovered genetic disorder, with high levels of lactic acid and low levels of the amino acid methionine in […]

2019-02-13, NEWS

The inflammatory shift of pregnancy

During pregnancy, the female body must balance the act of protecting the fetus against harmful microorganisms and maintaining a tolerance to paternal antigens from the fetus, in order to prevent rejection. In a novel paper by researchers from Uppsala University, a large shift in inflammatory status of women in late pregnancy and around two months […]

2019-02-12, NEWS

SciLifeLab enables genome sequencing breakthrough

A research group at Karolinska Institutet has sucessfully mapped three extremely complex chromosome aberrations by using pieces from four different DNA analyses. The project has received support from the SciLifeLab Swedish Genomes program. Researchers have spent two years trying to figure out what the genetic causes are for the severe symptoms that three individuals have […]

2019-02-12, NEWS

Small groups with big impact: antibiotic heteroresistance more common than thought

When selecting antibiotics for treatment of bacterial infections, physicians often rely on regular drug sensitivity tests conducted on bacterial samples from the patients. Still, treatments are sometimes unsuccessful. A new study led by Dan Andersson from Uppsala University provides evidence that heteroresistance, the presence of a resistant subpopulation in a main population of susceptible cells, is […]

2019-02-11, NEWS

SciLifeLab researchers among the most highly cited

Clarivate Analytics recently published their list of highly cited researchers from 2018. In total, 62 researchers from Sweden were on the list, and among them are five from SciLifeLab: Jens Nielsen (Facility Director at Systems Biology in Gothenburg), Rickard Sandberg, (Facility Director at Eukaryotic Single Cell Genomics), Erik Sonnhammer (Stockholm University), Ann-Christine Syvänen (Uppsala University, and Facility Director at […]

2019-02-11, NEWS

Receptor insights may lead way to custom-made cancer treatment

A recent study published in Nature Communications, co-authored by SciLifeLab Fellow Jens Carlsson (Uppsala University), has identified how a group of G protein-coupled receptors is affected by cancer mutations. This may lead to new drugs being developed. Class F, or Class Frizzled, is a group of of G protein-coupled receptors that are considered valuable therapeutic targets due […]

2019-02-11, NEWS

Molecular basis for the variability of mitoribosomes across species revealed

A collaborative effort between researchers from SciLifeLab, Georgia Institute of Technology and Harvard Medical School has revealed why mitochondrial ribosomes are highly variable across species. The study published and featured on the cover of the journal of Molecular Biology and Evolution, was led by SciLifeLab Fellow Alexey Amunts (Stockholm University/Karolinska Institutet), who also heads the cryo-EM lab. Despite a common ancestry, […]

2019-02-08, NEWS

Fat mass and fat-free mass found to have independent effects on atrial fibrillation

A recent study led by Erik Ingelsson (Uppsala University/SciLifeLab) has explored the association between body composition and atrial fibrillation – a common type of arrhythmia, or irregular heart rhythm. The effect of fat mass was shown to be independent, not mediated through the effect of fat-free mass. A globally aging population and growing obesity numbers […]

2019-02-06, NEWS

Ten Million Euro for Access to European Proteomics Facilities

The European Union has awarded 10 million euro to a consortium of eighteen European research groups in the field of proteomics research throughout Europe. One of these eighteen partners is the SciLifeLab Cell Profiling facility, offering spatial mapping of proteins at high resolution in cells and tissues. The European Proteomics Initiative Consortium (EPIC-XS), funded as part […]

2019-02-06, NEWS

SciLifeLab researchers explore environmental pollution and associated health risks in Bangladesh

The Swedish Research Council (VR), Sida, Formas and Forte have recently awarded funding for research on environmental pollution and associated health risks in Bangladesh. Oskar Karlsson and Jonathan Martin (Stockholm University/SciLifelab) were granted 5.6 million SEK to explore these issues. “The overall goal of our project is to screen, identify and determine levels of organic […]

2019-02-05, NEWS

Horses’ trotting racing ability undoubtedly polygenic

A recent study published in BMC Genomics has explored the genetics of trotting racing ability in horses. The study identified hundreds of candidate regions contributing to the horses’ trotting racing ability, which was described as “undoubtedly polygenic”. The results further suggest that racing ability may be a product of mental characteristics, not only physical ones. […]

2019-02-05, NEWS

Compressing entire labs into a computer chip

Once lab-on-a-chip (LOC) technology can be manufactured in a scalable cost-effective way, it could transform medicine in ways comparable with how microprocessors have changed our daily lives. In a new study reported in KTH News, a group led by SciLifeLab researcher Aman Russom (KTH) have developed a dispenser that could speed that revolution up.

2019-02-04, NEWS

Genes increase the risk of narcolepsy after Pandemrix vaccination

Genetic factors may increase the risk of severe unusual side-effects from the influenza vaccine Pandemrix. This was found in a recent study by the national project Swedegene, a collaboration between Uppsala University, Karolinska Institutet and the Swedish Medical Products Agency that study severe adverse reactions, with narcolepsy being one of them. The National Genomics Infrastructure (NGI) […]

2019-01-30, NEWS

8 million SEK to network for sample preparation expertise

An initiative to launch a network of regional hubs for sample preparation has been granted 8 million SEK in funding over four years from the Swedish Research Council (VR). Linda Sandblad, Head of Facility at the SciLifeLab Cryo-EM node at Umeå University, coordinates this project named NanoSPAM: National Nodes for Sample Preparation And Microscopy. It is […]

2019-01-30, NEWS

New method for rapid isolation of mitochondrial ribosomes

The group of SciLifeLab Fellow Alexey Amunts (Stockholm University/Karolinska Institutet) has published a new video on JoVE, describing their novel method for large-scale purification of intact ribosomes from human mitochondria. These mitoribosomes are central components of energy production, however their biochemical isolation was not well established. The described method, which has been developed at SciLifeLab, provides […]

2019-01-30, NEWS

Historical genomes reveal recent changes in eastern gorillas’ genetic health

The critically endangered Grauer’s gorilla, found in the Democratic Republic of the Congo, has declined by over 80 % in recent decades due to poaching and habitat destruction. The decline has resulted in harmful mutations and a loss of genetic diversity, according to a new study where historical and modern genomes of the gorilla have been compared.

2019-01-25, NEWS

Swedish forest soil microbes produce toxic mercury compound

The formation of the powerful neurotoxic methylmercury (MeHg) is a microbially mediated process that has raised much concern as it poses threats to both nature wildlife and human health. To understand the biogeochemical processes involved in the formation of this pollutant, researchers from Uppsala University have now mapped the microbial populations that contribute to MeHg […]

2019-01-25, NEWS

Newfound traits of myelin-producing cells in MS

In a recent study published in the journal Nature, researchers from Karolinska Institutet and the University of Edinburgh, UK, have investigated oligodendrocytes from deceased multiple sclerosis (MS) patients and discovered that subpopulations of these myelin-producing brain cells are altered in MS. The SciLifeLab Eukaryotic Single Cell Genomics facility enabled the determination of genetic activity of […]

2019-01-23, NEWS

Deeper knowledge of lichens’ complexity through DNA analysis

An individual lichen, which consists of fungi and algae living in symbiosis, can contain up to three different fungi. A discovery providing insight to another recent discovery showing lichens are made up of more than a single fungus and algae, overturning the prevailing theory of more than 150 years.

2019-01-21, NEWS

Genes influence where excess body fat is stored

A novel study led by Åsa Johansson (Uppsala University/SciLifeLab) reveals that genetic factors highly influence on whether your body stores fat around the arms, legs or trunk. The researchers have employed data from UK Biobank, a cohort study including half a million participants from the United Kingdom. Participants had given blood samples for genotyping as […]

2019-01-15, NEWS

SciLifeLab part of a major grant in forest genetic research

The Knut and Alice Wallenberg Foundation is investing over a 100 million SEK in research on tree genes, forest genetics and forest biotechnology. The project is a collaboration between SLU and SciLifeLab in Uppsala and Stockholm. The project focus on genomics and forest genetics and builds on a previous grant from the Knut and Alice […]

2019-01-14, NEWS

Restoring the differentiation and function in cryopreserved hepatocytes

Primary human hepatocytes are used in all areas of liver research, from in vitro studies of toxicity to clinically managing liver failure. The availability of these hepatocytes is, however, limited due to the problem of cellular stress during isolation and cryopreservation, causing a highly unpredictable loss of the ability to attach and form cell-matrix and […]

2019-01-14, NEWS

Subclasses of breast cancer-associated fibroblasts revealed

While cancer-associated fibroblasts (CAFs) are known to be a major constituent of the tumor microenvironment, their origin and roles in shaping disease initiation, progression and treatment response have remained unclear due to significant heterogeneity. Now, a research team led by Kristian Pietras from Lund University has discovered three distinct subpopulations of the cancer-associated fibroblasts.   […]

2019-01-11, NEWS

Olli Kallioniemi receives the Annual Research Prize of the Finnish Medical Society Duodecim

Photo: Mari Kaunisto Professor and SciLifeLab Director Olli Kallioniemi is a winner of the 2019 Matti Äyräpää Award. This prize is the most important national medical prize in Finland, which has been awarded annually by the Medical Society Duodecim since 1969. Olli Kallioniemi is awarded for his pioneering contributions to molecular precision medicine, to new technologies and […]

2019-01-09, NEWS

Advancing the understanding of endogenous DNA double-strand breaks

DNA double-strand breaks (DSBs) jeopardize genome integrity and might give rise to structural rearrangements associated with cancer, when repaired unfaithfully. In a new study led by SciLifeLab researcher Nicola Crosetto (Karolinska Institutet), a research team delves deeper into the matter. While exogenous agents such as chemotherapy and ionizing radiation can invoke the DSBs, a large amount […]

2019-01-07, NEWS

New analysis method for mapping proteins shared in an open database

A team of researchers at Karolinska Institutet and SciLifeLab have developed a new analysis method to map the localization of proteins in cells, information which they have shared in an open database accessible to researchers around the world. The study, published in Molecular Cell, was led by Professor Janne Lehtiö, SciLifeLab researcher and Facility Director for the SciLifeLab site of Chemical Proteomics & Proteogenomics.