NEW WEBSITE We would like to invite you to a sneak peak of our new website before it goes live. Visit the new site

News - 2017

2017-12-20, NEWS

Play tough or play nice: exploring invasion success in bacterial communities – a novel National Sequencing Project

  Assistant Professor Johan Bengtsson-Palme (University of Gothenburg) heads a biodiversity research project recently granted financing of large-scale sequencing via the SciLifeLab National Sequencing Projects initiative. SciLifeLab gave him a call to learn about the upcoming study of how the genetic composition of bacteria influences their ability to infiltrate an established biofilm. Congratulations Johan! Could you […]

2017-12-18, NEWS

The quest for genetic markers of adverse drug reactions – a novel National Sequencing Project

Professor Mia Wadelius (Uppsala University) is the principal investigator of a research endeavor recently granted funding through the SciLifeLab National Sequencing Projects initiative. SciLifeLab gave her a call to learn more about how her team contributes to the understanding of why some people get severe adverse effects from medical drug treatments while others do not. Congratulations Mia! You have been granted support […]

2017-12-13, NEWS

New initiative from SciLifeLab: research community programs

SciLifeLab research community programs (RCPs) To facilitate internationally competitive, cutting-edge collaborative research across Sweden, SciLifeLab will leverage its infrastructures to initiate a number of research community programs (RCPs).   Approach Through an open call for expressions of interest and a transparent evaluation process, SciLifeLab aims to profile its existing research community better, increase interactions between […]

2017-12-13, NEWS

Nobel Prize winners visit SciLifeLab

Left to right: Professor Brian Kobilka, SciLifeLab Director Professor Olli Kallioniemi, Professor Serge Haroche, Professor Edvard Moser, Professor Elizabeth Blackburn, KAW SAB chairman Professor Gunnar Öquist, Professor Frank Wilczek, Executive Director of KAW Board Göran Sandberg, Professor Dan Shechtman, Professor Roger Kornberg and SciLifeLab Co-Director Siv Andersson.   On December 12, SciLifeLab had the privilege […]

2017-12-12, NEWS

Celebrating the 2017 winners of the Science & SciLifeLab Prize for Young Scientists

      For many, the morning of December 11 is the day when the festivities and commending of scientific discoveries has come to an end, until next time. However, for this year’s awardees of the Science & SciLifeLab Prize for Young Scientists, it meant the beginning. During the day, the four winners got to […]

2017-12-08, NEWS

Alcohol-abuse drug potential cancer treatment

A new study, led by Jiri Bartek (Karolinska Institutet/SciLifeLab) has explored the potential for using disulfiram, also known as Antabuse – an old alcohol-aversion drug, to treat cancer. The results show an anti-cancer effect of the substance in a range of cancers including colon, prostate and breast cancer. The results are published in Nature.  Cancer incidence is rising and this global challenge is further […]

2017-12-08, NEWS

Enzyme that primes chromatin for DNA-repair has an on/off switch

  A study led by Sebastian Deindl (Uppsala University/SciLifeLab) now demonstrates the mechanisms behind how a portion of the chromatin-remodeling enzyme ALC1 acts as an on/off switch for its enzymatic activity. In the long-term, these results could potentially open up new horizons for therapeutic intervention strategies in cancer. Our genetic information is packaged into a […]

2017-12-07, NEWS

Winners of the Science & SciLifeLab Prize for Young Scientists 2017

SciLifeLab is proud to annonce this year’s winners of the Science & SciLifeLab Prize for Young Scientists. The four young scientists are have arrived in Sweden to receive their award and will hold presentations on their prizewinning research at the open scientific symposium Finding Your Way In Science in Aula Medica, Solna, on December 11.   Stilianos Louca […]

2017-12-07, PRESS

Pressmeddelande: Stort internationellt pris till excellenta unga forskare delas ut i Stockholm

Sveriges nationella center för molekylära livsvetenskaper, SciLifeLab, gör gemensam sak med tidskriften Science magazine och belönar unga forskningstalanger. Nu kommer årets vinnare till Stockholm för att ta emot sitt pris och presentera sina vinnande upptäckter. Den 11 december har festligheterna och hyllandet av vetenskapen för många nått sitt slut för denna gång. Men för fyra […]

2017-12-06, NEWS

Carolina Wählby elected new member of IVA

SciLifeLab congratulates Professor Carolina Wählby (Uppsala University/SciLifeLab) as she has been elected one of 18 new members of The Royal Swedish Academy of Engineering Sciences (IVA), an independent academy whose mission is to promote the engineering and economic sciences and the advancement of business and industry for the benefit of society. Carolina Wählby leads research in the field of Quantitative […]

2017-11-28, NEWS

33 milion SEK to support and advance large-scale genomic research in Sweden

SciLifeLab has now announced giving 33 million SEK to 14 sequencing projects focused on human whole genome sequencing and biodiversity under the SciLifeLab National Sequencing Projects initiative. In total, thousands of genomes will be sequenced within the projects. The SciLifeLab Board has announced its decision on funding 14 projects within the SciLifeLab National Projects initiative. […]

2017-11-28, PRESS

Pressmeddelande: 33 miljoner kronor till stöd och främjande av storskalig genomikforskning i Sverige

Vilken är den genetiska bakgrunden till att vissa människor drabbas av biverkningar vid medicinering, och hur påverkar antibiotika samspelet mellan olika bakterier? Frågor som dessa kommer nu kunna besvaras med hjälp av SciLifeLabs initiativ för att stödja och främja storskalig genomikforskning i Sverige. Fjorton forskningsprojekt inom hälsa och miljö får dela på totalt 33 miljoner kronor. Den tredje utlysningen av […]

2017-11-27, NEWS

The origin of a new species of Darwin’s finches

Darwin’s finches in the Galápagos archipelago provide an iconic model for the evolution of biodiversity on earth due to natural selection. A team of scientists from Princeton University and Uppsala University now reports that they have observed the origin of a new species using sequencing at the SciLifeLab National Genomics Infrastructure. The results show that […]

2017-11-22, NEWS

Bioconda – a community resource for bioinformatics software installation

The myriad of bioinformatics software opens great possibilities for biological and biomedical research, but with many programs and dependencies, software installations and updates often put a significant burden on Life Science researchers. Bioconda ( is an emerging public resource, aiming to make software installations easier and analyses more reproducible. In order to promote reproducible research and to […]

2017-11-17, NEWS

Dog owners at lower risk of dying prematurely

A study using Swedish national registries of more than 3.4 million Swedes aged 40 to 80 shows that dog owners had a lower risk of death due to cardiovascular disease or to other causes. The results may be explained by a higher level of physical activity among dog owners or effects of the dogs’ microbial flora on […]

2017-11-16, NEWS

NUDIX hydrolases may be used as biomarkers and novel drug targets of human diseases

A new study exploring the NUDIX hydrolases in human cells provides attractive opportunities for expanding the use of this enzyme family as biomarkers and potential novel drug targets. The NUDIX enzymes are involved in several cellular processes, yet their biological role has remained largely unclear. A highly collaborative study led by Professor Thomas Helleday (Karolinska […]

2017-11-15, NEWS

Mapping antibody mutations in humans provide new opportunities for creating therapeutic antibodies

Data from a new study on how antibodies are developed in humans can be utilized to improve the development of therapeutic antibodies for treating human diseases. Antibodies are key effector molecules in health and disease as they harbor the ability to recognize specific molecular structures and, consequently, elicit immune responses. The demand for and use […]

2017-11-13, NEWS

Breastfeeding does not protect children against asthma and allergies

The effect of breastfeeding on the risk of developing asthma and allergy has been debated for a long time. A new study led by Åsa Johansson (Uppsala University/SciLifeLab) show that breastfeeding might in fact increase the risk of developing hay fever and eczema, while not having any clear effect on the risk of asthma. Your risk of […]

2017-11-03, NEWS

Male mammoths were more prone to falling into natural death traps

  When researchers sequenced DNA from nearly a hundred woolly mammoth specimens using genomics service of SciLifeLab, they discovered that the majority of samples came from males. The explanation could be the risky behavior of male mammoths. A novel study led by Love Dalén from the Swedish Museum of Natural History has uncovered that out […]

2017-10-26, NEWS

Virtual screening for enzyme inhibitors enables efficient drug discovery

A recent study demonstrates that the use of virtual tools is an efficient way to discover chemical structures with the ability to inhibit enzyme activity. The project was led by Jens Carlsson (Uppsala University/SciLifeLab), in collaboration with Thomas Helleday (Karolinska Institutet/SciLifeLab).  An emerging strategy in early drug discovery entails using fragments, i.e. molecules smaller than conventional drug candidates, as […]

2017-10-18, NEWS

Four human genes connected to Obsessive Compulsive Disorder

The presence of several mutations in four important genes for the brain’s synapses can be associated to Obsessive Compulsive Disorder in humans. This is revealed through a study that included almost 600 patients and an about equal number of healthy controls. The investigations were led by Kerstin Lindblad-Toh (Uppsala University/SciLifeLab) in collaboration with a research team at Broad Institute, […]

2017-10-18, NEWS

Richer datasets from CRISPR/Cas9 screens using barcoded guide sequences

A novel study from researchers at Karolinska Institutet shows that by using so called random sequence labels, working as barcodes for tracing genetically altered cells, during CRISPR/Cas9 gene knock-outs it is possible to generate more comprehensive data from a smaller number of cells. The innovation has led to the SciLifeLab High Throughput Genome Engineering facility implementing barcodes in all future screening projects.  CRISPR/Cas9 gene […]

2017-10-17, NEWS

Facebook founder supports two SciLifeLab projects via global Human Cell Atlas effort

Two research projects based at SciLifeLab have been granted funding from the Chan Zuckerberg Initiative, which was formed by Facebook founder Mark Zuckerberg and his wife, Dr. Priscilla Chan, and provides financial and engineering support for the Human Cell Atlas – an ambitious international collaboration that aims to create a reference atlas of all cells in the healthy […]

2017-10-16, NEWS

Report on IAB evaluation of SciLifeLab available

The concluding report from the evaluation of SciLifeLab by the International Advisory Board (IAB) is now available (see below). It serves as a summary of the strategic evaluation performed by the IAB in March 2017 and provides feedback on several aspects of SciLifeLab operations to strengthen the development of the center. “The Science for Life […]

2017-10-05, NEWS

Electron microscopy technology offered at SciLifeLab gets awarded the Nobel Prize

On October 4, it was revealed that the 2017 Nobel Prize in Chemistry is awarded Jacques Dubochet, Joachim Frank and Richard Henderson for their development of cryo-electron microscopy (Cryo-EM) for the high-resolution structure determination of biomolecules in solution. Cryo-EM technology services is offered at SciLifeLab in Stockholm and Umeå as part of the national infrastructure resource. SciLifeLab Fellow (Stockholm University/SciLifeLab) Alexey Amunts and […]

2017-10-03, NEWS

Getting together

A big thank you to all of the SciLifeLab facility staff who met at our Facility Forum today to discuss important topics such as data management, teamwork and project models. Hopefully you also had the opportunity to network and get to know each other better. A special thank you to all of the staff who […]

2017-09-29, NEWS

Study presents how the ‘molecular scissors’ CRISPR-Cas9 search for specific DNA sequences

A study led by Johan Elf (Uppsala University/SciLifeLab) have demonstrated how the Cas9 component of the CRISPR-Cas9 genome editing technology is able to find the right DNA sequence. The results are published in Science magazine.  The CRISPR-Cas9 system has revolutionised biological research as it enables correcting or modifying essentially any DNA sequence. The hope is that these genetic scissors will […]

2017-09-29, NEWS

Genomic study reveals that modern humans emerged more than 300,000 years ago

A genomic analysis of ancient human remains from KwaZulu-Natal (South Africa) revealed that southern Africa has an important role to play in writing the history of humankind. The study was led by Mattias Jakobsson (Uppsala University/SciLifeLab) in collaboration with researchers from the Universities of Johannesburg and the Witwatersrand, South Africa. The team presents their results in the […]

2017-09-25, NEWS

NIH funding to Marcel den Hoed

Marcel den Hoed (Uppsala University/SciLifeLab) is a co-applicant of a project that was recently awarded a grant from the American NIH. The project will address the link between obesity and cardiometabolic complications and is a collaboration between researchers from USA, UK and Sweden. The project, led by Ruth Loos at Icahn School of Medicine at Mount […]

2017-09-20, NEWS

Mathias Uhlén receives research award from Forska!Sverige

The non-profit foundation Forska!Sverige in Sweden has announced that the 2017 recipient of their researcher’s award is Mathias Uhlén, Professor at KTH Royal Institute of Technology and a SciLifeLab faculty member. Mathias Uhlén was also the former Director of SciLifeLab. He receives the Forska!Sverige award for his work on mapping the human proteome. Read the press […]

2017-09-19, NEWS

Uppsala SensUs team receive international award for smartphone biosensor

The Uppsala SensUs student team of 2017 called UppSense has recently received a creativity award at the international SensUs competition at Eindhoven University of Technology. Team UppSense has been supported by SciLifeLab and were awarded for their design of a cheap biosensor which could allow patients to monitor the well-being of their heart at home using their […]

2017-09-19, NEWS

Exploring the relationship between epigenetic changes and protein biomarkers levels

A new study, published in PLOS Genetics, reveals that the associations found between epigenetic patterns and levels of protein biomarkers are likely to reflect the underlying pattern of genetic variants, specific environmental exposures or represent secondary effects following the disease pathogenesis.  The investigation, led by Åsa Johansson (Uppsala University/SciLifeLab), combined data on e.g. DNA methylation levels, an epigenetic feature, with measurements of  protein […]

2017-09-07, NEWS

Three SciLifeLab researchers get ERC Starting Grants 2017

Three researchers from the SciLifeLab community have received starting grants from the European Research Council, ERC, 2017. Tanja Slotte (Stockholm University/SciLifeLab), Marc Friedländer (Stockholm University/SciLifeLab), both SciLifeLab fellows, and SciLifeLab faculty member Maria Tenje (Uppsala University/SciLifeLab) all receive up to EUR 1.5 million for up to 5 years. ERC Starting Grants are designed to support young research leaders with proven potential […]

2017-09-06, NEWS

Potential new indications of Temodex revealed through Drug Discovery and Development platform project

Double Bond Pharmaceutical has during the summer carried out and completed a successful collaborative project with the In vitro and Systems Pharmacology facility within the SciLifeLab Drug Discovery and Development platform.  The goal was to deepen the knowledge about the pharmacological and cytotoxic effects of the drug Temodex in vitro in different human brain cancer cell lines. Temodex is […]

2017-08-30, NEWS

Welcoming a new student class to joint Master’s programme

On August 24, this year’s class of the Master’s Programme in Molecular Techniques in Life Science begun their studies. We wish them a great two years at Karolinska Institutet, Stockholm University, KTH Royal Institute of Technology  – and, of course, at SciLifeLab. The Master’s Programme is a unique collaboration between the three universities and the students […]

2017-08-30, NEWS

Frontline techniques reveal immune system dynamics after immunotherapy

By combining new systems biological analyses and advanced data analysis, a recent study led by Petter Brodin (Karolinska Institutet/SciLifeLab) have been able to monitor the maturation process of the immune system in leukaemia patients who have undergone stem cell transplantation. The findings reveal patterns that can be linked to clinical complications in the patients. Allogeneic […]

2017-08-29, NEWS

New candidate gene for dyslexia discovered

A new study, led by Juha Kere (KI/SciLifeLab), has uncovered a link between a variant of the NCAN gene and developmental dyslexia. The results, published in Scientific Reports, also shows that this NCAN type is associated with volumes of certain brain regions in young adults and infants.  Developmental dyslexia involves troubles with accurate and/or fluent word recognition and spelling, despite sufficient intelligence and […]

2017-08-23, NEWS

Millions of novel genetic variants found in 1000 Swedish individuals

The results from the SweGen project are published today. Within the SweGen project, large-scale DNA sequencing methods were used to analyse the whole genome of 1000 individuals from different parts of the country. In total 33 million genetic variants were detected, of which 10 million are novel and not reported in current databases. The variant […]

2017-08-23, NEWS

Novel drug targets for treating fatty liver disease and liver cancer identified

The quest for effective treatment against liver cancer and fatty liver disease, has made huge progress as a study led by SciLifeLab Fellow Adil Mardinoglu (KTH) has identified a number of drug targets that can be used in the development of new efficient treatment strategies with minimum side effects. The results were published in Molecular […]

2017-08-18, NEWS

New Pathology Atlas maps genes involved in cancer to accelerate personalized medicine

A new Pathology Atlas is launched today with an analysis of all human genes in all major cancers showing the consequence of their corresponding protein levels for overall patient survival. The difference in expression patterns of individual cancers observed in the study strongly reinforces the need for personalized cancer treatment based on precision medicine. In […]

2017-08-16, NEWS

Mapping of moose’s gut flora propels development of future biofuels

Through sequencing of ninety-nine moose stomach microbiomes, a study led by Anders Andersson (KTH/SciLifeLab) and Henrik Aspeborg (KTH) has provided new insights into microbial plant biomass degradation. The findings from the current project are highly relevant to the development of the second generation of biofuels. Using enzyme technologies converting forestland material into e.g. ethanol would offer […]

2017-08-10, NEWS

Ultrafast test for antibiotic susceptibility through single-cell imaging

A new study led by Johan Elf (Uppsala university/SciLifeLab) demonstrates that it is possible to determine in 30 minutes if a urinary tract infection is caused by antibiotics-resistant bacteria. Tailoring treatment against bacterial infections can help reduce unnecessary and incorrect use of broad-spectrum antibiotics, which aggravates the antibiotics resistance problem and poses a global threat to human health.  One way to […]

2017-08-09, NEWS

Receptor dynamics open up new possibilities for drug development

Novel findings reveal that G protein-coupled receptors, which have previously assumed to be statically configured as monomers or dimers, can switch between the two arrangements under different conditions. This provides new strategies for drug development, as separation or joining may be inhibited or triggered.    G protein-coupled receptors, a common type of protein in the […]

2017-08-08, NEWS

Childhood adiposity genes associated with risk for type 1 diabetes

A study led by Tove Fall (Uppsala University/SciLifeLab) shows that genetic variants associated with childhood body mass index (BMI) can be linked to the occurrence of type 1 diabetes. The results, published in PLOS Medicine, provides evidence that could be part of the explanation behind todays’s increased rates of type 1 diabetes.  Type 1 diabetes (T1D) rates have been increasing globally […]

2017-08-07, NEWS

Orientation of membrane proteins remains fixed

Membrane proteins are thought to attain their unique orientation very early, already when they are being produced. Flipping the pre-set orientations of proteins in the membrane was always believed to be an impossible process. However, recent studies have cast doubt on this view, causing a debate. Now, a paper published in PNAS, instead confirms the prevailing assumption that […]

2017-08-02, NEWS

Simple sugar reveals risk for type 2 diabetes and cardiovascular disease

A current study uncovers that measuring blood level of mannose, a simple sugar molecule that is part of many naturally occurring polysaccharides, can be used to forecast a person’s probability of developing type 2 diabetes, cardiovascular disease and progression of diabetic kidney disease.  The paper, authored by Adil Mardinoglu (KTH/SciLifeLab) shows that high basal levels of mannose predicts future […]

2017-08-01, NEWS

Blocking of enzyme halts brain tumour cell growth

By blocking of an enzyme that affects the cellular microenvironment it is possible to stop brain tumour cells from growing. This is shown in a new study published in Molecular Cancer Therapeutics. Brain tumours constitute 25% of all childhood cancers. Among those are malignant forms such as medulloblastoma, a cancer of the cerebellum. Today, more […]

2017-08-01, NEWS

Long-lived sperms generate fitter offspring

Males produce hundreds of thousands to hundreds of millions of sperms in one single ejaculation, depending on the species. Does it matter which one that actually fertilizes the egg? A recent paper published in in PNAS reveals that selection of long-lived sperms from the male ejaculation results in offspring with greater prospects of surviving early […]

2017-08-01, NEWS

Innovative tool determines immune system differences in humans

Immune system function varies significantly between individuals, and up to now there has been no effective means of measuring and describing these differences. Now, a study led by Petter Brodin (Karolinska Institutet/SciLifeLab)  shows that white blood cell composition is unique in individuals, and that the composition of these cells may predict immune system responses. The […]

2017-08-01, NEWS

Novel method for studying bioavailability – a potential shortcut in drug development

A paper published in Proceedings of the National Academy of Sciences (PNAS) reveals a method for quantifying the intracellular bioavailability of drug molecules and thereby predict the drug’s access to intracellular targets as well as the resulting pharmacological effect.  Knowledge of the amount of drug that is available to bind targets inside cells provides a powerful tool for compound selection in early […]

2017-08-01, NEWS

New approach for virus RNA visualization can help predict pandemics

A recent paper published in Cell Reports presents a new technique for analyzing the whereabouts of influenza virus genetic segments in cells and tissues. The study, co-led by Mats Nilsson (Stockholm University/SciLifeLab) provides new strategies for evaluating how new mutations affect pathogenicity and identifying properties that enable or restrict influenza gene segment reassortment that give rise to to […]

2017-06-30, NEWS

SciLifeLab researcher Óscar Fernandez-Capetillo awarded Erik K Fernström prize

Óscar Fernandez-Capetillo, professor of cancer therapy at Karolinska Institutet since 2015 and a SciLifeLab faculty member, has been awarded the Erik K Fernström prize for his pioneering research on how DNA damage can lead to cancer and ageing. Óscar Fernandez-Capetillo‘s research focuses on replicative stress and replicative damage to DNA, which causes ageing, as well as cancer. His research interest lies […]

2017-06-29, PRESS

Chemical Biology Consortium Sweden enters research collaboration with AstraZeneca

Chemical Biology Consortium Sweden (CBCS), an integrated part of SciLifeLab, today announced a new research collaboration with AstraZeneca. The partnership will give Swedish academic researchers access to AstraZeneca’s annotated small molecule compound library with the aim of identifying novel protein targets aligned to key unmet medical needs. Projects are expected to focus on so-called phenotypic […]

2017-06-28, NEWS

Three SciLifeLab researchers granted SSF funding for systems biology projects

Olli Kallioniemi (Karolinska Institutet), Sten Linnarsson (Karolinska Institutet) and Sven Nylander (Uppsala University), all SciLifeLab faculty members, have been granted five years funding from SSF – Stiftelsen för strategisk forskning. The call was designed to support projects within systems biology, an emerging field of research aimed to understand complex relationships and interactions between components in biological systems. They […]

2017-06-28, PRESS

National network for future leaders in life science launched by SciLifeLab and Wallenberg Centers for Molecular Medicine

SciLifeLab (Science for Life Laboratory), a national center for biomolecular sciences, and the Wallenberg Centers for Molecular Medicine (WCMM) in Gothenburg, Linköping, Lund and Umeå have formed a collaborative network to bring together the future leaders of life science and molecular medicine in Sweden. SciLifeLab and WCMM have initiated an official collaboration, co-funded by a […]

2017-06-28, NEWS

The Human Cell Atlas selected as one of ten emerging technologies to make a change to society

This week, Scientific American announced ten emerging technologies with innovations that are on the verge of changing society. One of the technologies selected was the Human Cell Atlas, which aims to integrate research exploring the building-blocks of human cells using new emerging technologies. One of the projects underlying the Human Cell Atlas is the Human […]

2017-06-22, NEWS

Vaginal microbiome study initiated at the Center for Translational Microbiome Research

To define the composition of the vaginal microbiome in healthy and pregnant women, a number of large clinical studies have now been initiated by the Center for Translational Microbiome Research (CTMR) in collaboration with Uppsala University Hospital. CTMR started in January 2016 as collaboration between SciLifeLab, KI and the Swiss company Ferring Pharmaceuticals to establish a broad technical, […]

2017-06-22, NEWS

National Projects proposals up for review

The 2017 call for proposals for SciLifeLab National Projects in genomics have now closed and the 48 submitted projects (representing total project budgets of 180 MSEK) will undergo peer review during the summer. A final decision which projects that will get to share the 30 MSEK allocated to the National Projects is expected from the SciLifeLab Board […]

2017-06-15, NEWS

Antibody validation rewrites the story of Estrogen Receptor beta

  A new study by Cecilia Williams (KTH/ SciLifeLab) and colleagues uncovers that the notion of estrogen receptor beta playing a role in breast cancer is based on analyses with inadequate antibodies. The results show that other proteins are mistakenly identified as ERβ, which cannot even be detected in breast cancer tissue when using the […]

2017-06-07, NEWS

Synchrotron scanning uncovers the contents of fossil faeces in 3D

For the first time, imaging of coprolite, i.e. fossil faeces, contents in three dimensions using synchrotron tomography has been carried out successfully. This provides a novel approach for revealing the diet, and thereby also the lifestyle, of ancient animals such as dinosaurs.  The study investigated 230 million years old coprolites from Poland and was led by Per Ahlberg (Uppsala University/SciLifelab) in collaboration […]

2017-06-01, NEWS

First graduating class from Master’s programme in Molecular Techniques in Life Science

On June 1, SciLifeLab congratulated the first class to graduate from the Master’s programme in Molecular Techniques in Life Science. They have received a joint degree from three universities as this programme is a unique collaboration between Karolinska Institutet, KTH Royal Institute of Technology and Stockholm University, in the environment of Science for Life Laboratory. The students have […]

2017-05-31, NEWS

Tea consumption leads to epigenetic changes in women

Epigenetic changes are chemical modifications that switch on or off genes. A study led by Åsa Johansson (Uppsala University/SciLifeLab) uncovers that tea consumption in women leads to DNA methylation of genetic regions associated with cancer and estrogen metabolism. It is well known that our environment and lifestyle factors, such as food choices, smoking and exposure to chemicals, can lead to […]

2017-05-30, NEWS

Ancient genetic adaptations in mountain-living honeybees revealed

A new study published in PLoS Genetics ascribes the adaptations in honeybees that reside at high altitudes to ancient genetic alterations. The researchers sequenced the genomes of Kenyan honeybees from mountain forests or lowland savannahs and uncovered that regions located on chromosome 7 and 9 were consistently different between the two populations. This could explain […]

2017-05-24, NEWS

New BLISS technique – one step closer to genome editing in living organisms

To be able to edit DNA in living organisms would provide significant opportunities for advances in medicine, as well as agricultural biology. The CRISPR-based tool is a promising approach, which has now progressed further as Nicola Crosetto (Karolinska Institutet/SciLifeLab) and his colleagues present the novel BLISS method for identifying DNA double-strand breaks in tissues. The […]

2017-05-22, NEWS

Proteins stay intact in dried blood samples

A drop of blood on filter paper, allowed to dry and kept until diagnosis – a considerably easier option than the present-day, resource-consuming method using frozen blood samples in plastic tubes. This current study from Uppsala university/SciLifeLab have successfully measured 92 different proteins in millimetre-sized circles punched out of dried samples. The results opens new doors for health care as resources can […]

2017-05-18, NEWS

First issue of Synergy magazine available

The first issue of Synergy magazine is now available. It is a biannual publication highlighting research enabled by SciLifeLab infrastructure services – and the scientists behind it. Click here to read the magazine online (Swedish or English) or order your own copy or subscribe at no cost.

2017-05-18, NEWS

Siv Andersson new Co-Director for SciLifeLab

Siv Andersson, professor of molecular evolution at Uppsala University, has been appointed Co-Director of SciLifeLab by the SciLifeLab national board. She will start her duties in the SciLifeLab management group by July 1st, when Lena Claesson-Welsh is stepping down from the Co-Director position. Currently, Siv Andersson is Facility Director at Bioinformatics Long-term Support (WABI) and a SciLifeLab […]

2017-05-12, NEWS

First subcellular map of proteins gives new insights in human biology

The first analysis of how proteins are arranged in a cell reveals that a large portion of human proteins can be found in more than one location in a given cell. The study, published in Science, was led by Emma Lundberg, KTH/SciLifeLab and responsible for the High Content Microscopy facility at SciLifeLab. Using the Sweden-based […]

2017-05-09, NEWS

Time- and cost effective monitoring of the Baltic Sea with DNA sequencing

DNA sequencing technology is developing fast and as a result more applications arise. The smallest sequencing instruments today corresponds to the size of a cellphone, as does their price tag. Anders Andersson, KTH Royal Institute of Technology/SciLifeLab and his colleagues are using the technology to monitor the aquatic environment of the Baltic Sea. “We use […]

2017-05-03, NEWS

A picture is worth a thousand words

On May 3, about 300 researchers participated during SciLifeLab Science Summit – Imaging the Complexity of Life. The day offered presentations, art exhibition and ample mingle opportunities.   This year’s SciLifeLab Science Summit focused on the impact of bioimaging, Whether on atomic or tissue level. Movements within the cell Both national and international speakers lined […]

2017-04-24, NEWS

New supercomputers will strengthen important research

Today the two supercomputers Bianca and Rackham are inaugurated at Uppsala University. Bianca, that will store data from human samples, will be available for researchers at SciLifeLab and their partners via SNIC through the National Bioinformatics Infrastructure Sweden (NBIS) platform at SciLifeLab. “These new compute and storage resources will enable SciLifeLab researchers to carry out complex […]

2017-04-20, PRESS

SciLifeLab offers funding for national genomics studies

SciLifeLab welcomes applications for Swedish research projects based on next generation DNA sequencing. In total, this third call will provide 30 million SEK in support for sequence analysis of unique and well-characterized sample collections to study either the genetic basis of disease or environmental effects on biodiversity. The Swedish Genomes Program and the Swedish Biodiversity […]

2017-04-19, NEWS

New study reveals how some chickens got striped feathers

Birds show an amazing diversity in plumage color and patterning. But what are the genetic mechanisms creating such patterns? In a new study published in PLOS Genetics, led by Leif Andersson, Uppsala University/SciLifeLab, Swedish and French researchers report that two independent mutations are required to explain the development of the sex-linked barring pattern in chicken. […]

2017-04-19, NEWS

Ingvar Carlsson Award to Mikael Sellin

SciLifeLab Fellow Mikael Sellin, Uppsala University, is one of twelve young researchers who receives the Ingvar Carlsson Award 2017. The grant is awarded by The Foundation for Strategic Research, SSF, and gives each researcher 4 million SEK and a personal grant of 60 000 SEK as well as participation in a leadership program. Mikael Sellin gets […]

2017-04-06, NEWS

Genes key to killer bee’s success

In a new study, researchers led by Mathew Webster, Uppsala University/SciLifeLab, sequenced the genomes of Africanized bees that have invaded large parts of the world to find out what makes them so extraordinarily successful. One particular region in the genome caught the researchers’ attention and the genes found there could be part of the explanation […]

2017-04-04, NEWS

The genetic basis for timing of reproduction in the Atlantic herring revealed

Animals need to breed at the time of year when their progeny have the best chance of survival. In a study published today in PNAS, scientists in Sweden and Canada, led by Leif Andersson at Uppsala University/SciLifeLab, have studied the genetic basis of reproduction in 25 populations of herring from both sides of the North […]

2017-03-23, NEWS

Richard Rosenquist Brandell appointed Wallenberg Clinical Scholar

Richard Rosenquist Brandell, Uppsala University/SciLifeLab, Platform Director for Diagnostics Development and Head of Facility for Clinical Genomics Uppsala, has been appointed Wallenberg Clinical Scholar by The Kut and Alice Wallenberg foundation. As a Wallenberg Clinical Scholar, Richard Rosenquist Brandell will use the infrastructure for large-scale investigation of cells and their genetic material at SciLifeLab to […]

2017-03-07, NEWS

New treatment attacks liver disease and type 2 diabetes

A research team involving Adil Mardinoglu and Mathias Uhlén at KTH Royal Institute of Technology/SciLifeLab are planning a clinical trial of a new treatment for nonalcoholic fatty liver disease and type 2 diabetes. The treatment harnesses liver cells’ own ability to burn accumulated fats. The team used a metabolic modeling approach, which relied on data […]

2017-03-06, NEWS

Nominate your favorite speaker

SciLifeLab The Svedberg Seminar series is a distinguished speaker series within the field of biosciences and holds research seminars given by leading scientists from Sweden and worldwide. SciLifeLab The Svedberg committee now invites you to nominate speakers of your interest. This is an excellent opportunity for your research group and students to extend their network and engage in scientific […]

2017-03-06, NEWS

Jens Carlsson gets ERC Starting Grant

The European Research Council, ERC, has decided to grant SciLifeLab fellow Jens Carlsson, Uppsala University/SciLifeLab, the ERC Starting Grant for 2016. Earlier it was announced that Magda Bienko, Sebastian Deindl, and Simon Elsässer, all SciLifeLab fallows, will receive this grant of up to EUR 1.5 million for up to 5 years.

2017-03-02, NEWS

VR grants for research environments to SciLifeLab

The Swedish Research Council (VR) has made decisions regarding Grants for research environment in science (Bidrag till forskningsmiljö inom teknik och naturvetenskap). The purpose of the grant is to create added value of cooperation in a group that is larger than in a regular research projects. Of the 222 applications that came in only 18 […]

2017-02-23, NEWS

Contrasting sex bias in Neolithic and Bronze Age migrations to Europe

A new study, looking at the sex-specifically inherited X chromosome of prehistoric human remains, shows that hardly any women took part in the extensive migration from the Pontic-Caspian Steppe approximately 5,000 years ago. The great migration that brought farming practices to Europe 4,000 years earlier, on the other hand, consisted of both women and men. […]

2017-02-22, NEWS

New SciLifeLab fellow focuses on environmental questions

Sari Peura is trying to understand how microbes control the carbon cycle in habitats where the food web is sustained by external organic carbon inputs. Many of the microbes in these environments are poorly known and understood and Sari hopes that her findings will contribute to understanding how microbes are mitigating greenhouse gas emissions from […]

2017-02-13, NEWS

Extensive computations and structural illumination (SIM) super-resolution microscopy reveal plant secrets

Using extensive and novel computational approaches, molecular biology experiments, and structural illumination (SIM) super-resolution microscopy, researchers at KTH Royal Institute of Technology/SciLifeLab and Swedish University of Agricultural Sciences, has shown that the development of stamens in Arabidopsis thaliana is coordinated by several genes close to each other in the plant chromosome. According to the findings it seems that regulation […]

2017-02-13, NEWS

Blooming algea can increase mercury methylation

Researchers from Uppsala and Umeå University have found that the formation of methylmercury in sediment is controlled by the molecular composition of organic matter. Three of the authors are affiliated to SciLifeLab: Andrea G Bravo, Stefan Bertilsson and Alejandro Mateos-Rivera. The study has been published in Nature Communications. Read full press release Read scientific article

2017-02-08, NEWS

SEK 123 million to SciLifeLab researchers

Swedish Foundation for Strategic Research (SSF) has granted seven Swedish researchers support within their call “Big Data and Computational Science”. Four of these are active at SciLifeLab and are granted a total of SEK 123 million:  Sven Nelander gets SEK 33 milllion for his project “Integrative precision medicine: local data, global context” Nicola Crosetto gets […]

2017-01-31, NEWS

New platform structure and facilities

Following the evaluation of the SciLifeLab infrastructure in 2016, the SciLifeLab Board decided on the budget for the facilities for 2017-2018. In addition, the platform structure of the center has been reorganized as shown at Technologies & Services. “The reorganization is in line with the SciLifeLab mission to provide front line technologies for the benefit of […]

2017-01-30, NEWS

Brain tumours’ origin affects their malignancy and drug sensitivity

Patients with glioblastoma have very poor prognosis since there are no effective therapies. In a study published in Cell Reports, researchers led by Lene Uhrbom, Uppsala Univeristy/SciLifeLab, have discovered a correlation between the cell type from which the tumor originates and the growth and drug sensitivity of the tumor. More knowledge about the mechanisms behind […]

2017-01-30, NEWS

Collaboration between SciLifeLab and Karolinska University Hospital leads to breakthrough for improved treatment of leukemia

Researchers at SciLifeLab has together with research physicians at Karolinska University Hospital and scientists at Heidelberg University identified a key player determining response to cytarabine – the most important drug against acute myelogenous leukemia. The results were presented in Nature Medicine. Approximately 350 000 people are diagnosed with acute myelogenous leukaemia (AML) every year worldwide. […]

2017-01-26, NEWS

Starting research school in Medical Bioinformatics

The future of life science will be created by scientists that master advanced computational methods for dealing with big-data from high-throughput biotechnological methods, and study the most important medical problems, such as how to cure cancer and improve health. To meet this need, the Swedish National Research School in Medical Bioinformatics is now being started. It is […]

2017-01-20, NEWS

Are you our new Co-Director?

SciLifeLab is looking for a new Co-Director following the board’s decision to announce this post in an open call since Lena Cleasson-Welsh finishes her interim assignment in the summer of 2017.  The Co-Directorship represents a 50% time commitment that can be combined with a professorship (100%) at Uppsala University. The position is open for scientists already […]

2017-01-19, NEWS

New organizational structure and management group

Starting in 2017, SciLifeLab launches a new simplified organizational structure. The management group (MG) now consists of the Director, Co-Director, Infrastructure Director and four Scientific Directors, involving representation of the four primary host universities. The previous Site Director positions in Uppsala and Stockholm have been replaced by four Scientific Directors (SD:s) representing the four host […]

2017-01-18, NEWS

DNA-sequencing with cell phone provides fast diagnosis

An international research team led by Mats Nilsson at Uppsala University and Stockholm University/SciLifeLab has developed a small, 3D-printed microscope that is connected to an ordinary cell phone. Using the device, physicians can diagnose diseases like cancer and tuberculosis. It is also possible to send pictures and sequencing information to physicians in other parts of […]

2017-01-16, PRESS

Pelago Bioscience and CBCS at SciLifeLab enters collaboration agreement

Pelago Bioscience AB and Chemical Biology Consortium Sweden (CBCS), the chemical biology facility at Karolinska Institutet and SciLifeLab (Science for Life Laboratory) today announced that they will collaborate to develop high throughput automated CETSA®-based Target Engagement Assays for multiple targets. The collaboration is based on expanding Pelago’s CETSA technology capabilities and will enable screening of […]

2017-01-13, NEWS

Inhibition of EZH2 protein could treat multiple myeloma

A study led by Helena Jernberg Wiklund, Uppsala University/SciLifeLab, shows how the protein EZH2 affects the development of multiple myeloma, and that inhibition of EZH2 could be used as a new strategy to treat the disease. The cancer form multiple myeloma is today incurable and it has been challenging to improve therapy. The study was published […]

2017-01-12, NEWS

Asgard archaea explains how cells became complex

In a study published in Nature, an international research group led by Thijs Ettema, Uppsala University/SciLifeLab, presents the discovery of a group of microbes called Asgard archaea. The study provides new insights in how eukaryotic organisms gradually evolved from simpler microbial ancestors. “These organisms are our closest microbial relatives, and we know next to nothing […]

2017-01-09, NEWS

Welcome Mikael Sellin, our newest SciLifeLab fellow!

He is a cell biologist who did his Post Doc in a microbiology lab. Now he hopes to help fighting emerging bacterial disease, using new models for microbial gut infections. Mikael Sellin is a SciLifeLab fellow since December 2016. “When you hear clinicians talk about antibiotic resistance it gives you chills down your spine, that […]

2017-01-09, NEWS

Lena Claesson-Welsh is Cancer researcher of the year

SciLifeLab’s Co-Director Lena Claesson-Welsh has been named Cancer researcher of the year (Årets cancerforskare) by Cancerfonden and receives 6 million SEK during three years.  “It feels amazing to be named Cancer researcher of the year by Cancerfonden. My research team is trying to understand how blood vessels in tumors are regulated which in turn hopefully will […]