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News - 2016

2016-12-22, NEWS

24 million SEK to SciLifeLab fellows

Two SciLifeLab Fellows: Alexey Amunts and Kristina Jonas, have received grants from the Swedish Foundation for Strategic Research (SSF) within their program for young researchers (Framtidens Forskningsledare).

2016-12-20, NEWS

WABI collaboration enables rapid production of individualized V gene databases

The adaptive immune system has the capacity to produce antibodies with enormous numbers of binding specificities. Antibodies are generated through recombination of a fixed set of germline immunoglobulin segments, called V genes, with other germline immunoglobulin segments. The exact composition of germline V gene sequences in an individual has been difficult to determine due to […]

2016-12-15, NEWS

Hello there Per-Olof Syrén…

….KTH Royal Institute of Technology/SciLifeLab, who recently started a new research project in collaboration with the industry, what is it that you are going to do? “Our aim is to develop new biomaterials from renewable sources using enzymes that could convert the raw material, wood, into something new. Main partners are Holmen who handles the […]

2016-12-14, NEWS

Popular symposium with praised young researchers

On December 9, the four winners of Science & SciLifeLab Prize for Young Scientists held presentations about their research at SciLifeLab in Solna. Almost 100 people came to listen to the young researchers as well as to Editors from Science who also presented during the seminar. Director Olli Kallioniemi opened the symposium and was followed […]

2016-12-08, NEWS

One specific gene explains many diseases

Genetic differences in the FADS1 gene determine the risk for many different diseases. The ability to produce polyunsaturated fats like omega-3 and omega-6 differs between individuals and this affects the risk for disturbed metabolism, inflammatory diseases and several types of cancer. Scientists at SciLifeLab/Uppsala University led by Claes Wadelius have clarified this in detail and the […]

2016-12-05, NEWS

Cell of origin influences glioma development and phenotype

Children with the malignant brain tumor form high-grade malignant glioma often have a very poor prognosis. The knowledge about how this cancer form arises and develops is still limited but new results from a research team led by Lene Uhrbom, Uppsala University/SciLifeLab, shows that disease progress and the malignancy are affected by the cell type […]

2016-12-05, NEWS

Showing location of proteins in cells opens a new chapter in human biology

A new chapter of the Human Protein Atlas, HPA, has been launched: The Cell Atlas – an open-access interactive database of images showing the location of over 12,000 proteins in cells.

2016-12-02, NEWS

Four SciLifeLab researchers appointed Wallenberg Academy Fellows

In total 29 new Wallenberg Academy Fellows have been appointed within the Knut and Alice Wallenberg Foundation’s investment program in young researchers 2016.  Four of these are active at SciLifeLab: Maria Tenje, Uppsala University/SciLifeLab Emma Lundberg, KTH Royal Institute of Technology/SciLifeLab Vicente Pelechano, Karolinska Institutet/SciLifeLab and SciLifeLab fellow Claudia Kutter, Karolinska Institutet/SciLifeLab and SciLifeLab fellow The […]

2016-12-02, NEWS

The difference between expectations and reality is key to learning

Neir Eshel, psychiatry resident at Stanford University, has discovered how interactions between brain neurons make us able to predict the consequence of a certain behavior. For these findings he has now been named Grand Prize Winner of Science & SciLifeLab Prize for Young Scientists. Eshel is particularly excited about the possible implications for his patients, […]

2016-11-30, NEWS

Novel library preparation for whole genome DNA methylation sequencing

NGI Uppsala (SNP&SEQ Technology) platform has developed a novel approach for quick and cost effective whole genome bisulphite sequencing (WGBS) library preparation. Compared with currently used commercial methods, this method called  SPLinted Adaptor Tagging (SPLAT) has the major advantage of uniform coverage of the genome. SPLAT is based on initial bisulphite treatment of the DNA, followed […]

2016-11-29, NEWS

Director Olli Kallioniemi comments on the research bill

On November 28, the Swedish Minister for Higher Education and Research, Helene Hellmark Knutsson, presented the research bill for 2017-2020 at SciLifeLab in Solna. “The bill gives SciLifeLab the same level of funding as during the last period, providing continuity and long-term perspective for developing SciLifeLab forward”, said SciLifeLab Director Olli Kallioniemi. Professor Kallioniemi continued: […]

2016-11-28, NEWS

Three SciLifeLab researchers elected members of IVA

The Royal Swedish Academy of Engineering Sciences, IVA, has elected 20 new members at their latest assembly. Among the new members are Helene Andersson Svahn at KTH Royal Institute of Technology/SciLifeLab, Jerker Widengren at KTH Royal Institute of Technology/SciLifeLab and Anna Wedell at Karolinska Institutet/SciLifeLab. IVA is an independent academy with 1,300 elected Swedish and […]

2016-11-22, NEWS

New support function for data management

The SciLifeLab national platforms produce a massive amount of experimental data for Swedish research projects. Turning this data into new science is rapidly increasing the needs for bioinformatic support and efficient management of data. To maximize the impact of the data that SciLifeLab generates, the SciLifeLab board has decided to establish a new support function, […]

2016-11-14, NEWS

Genetic connection to Addison’s disease revealed

A team of researchers led by Gerli Rosengren Pielberg, Uppsala University/SciLifeLab, have found a gene that is strongly connected to the autoimmune Addison’s disease. The discovery has been enabled by the Swedish Addison registry and the result was published in Journal of Internal Medicine. Read full press release (in Swedish)  Read scientific article

2016-11-07, NEWS

SciLifeLab researchers among the most highly cited

Clarivate Analytics, Formerly the IP & Science business of Thomson Reuters, recently published their list of highly cited researchers 2016. In total, 27 researchers in Sweden were listed and among them are two from SciLifeLab: Erik Sonnhammer, SciLifeLab Faculty at Stockholm University, and Jens Nielsen, Facility Director at Systems Biology located in Gothenburg. Congratulations!

2016-11-02, NEWS

International student competition on molecular biosensors open

Students from different interdisciplinary programs at Uppsala University are invited to build a scientific team with broad skills to work with different research groups and develop a molecular biosensor. SensUs is an international student competition on molecular biosensors for healthcare applications, supported by SciLifeLab. Ten universities from three continents, including Uppsala University, will participate in […]

2016-10-28, NEWS

Important link found between genomics and proteomics

Several previous reports have concluded that RNA levels cannot be used to predict protein levels. However, in a new study from KTH Royal Institute of Technology/SciLifeLab published in the journal Molecular Systems Biology, scientists show that protein levels can be predicted from RNA levels if a gene-specific RNA-to-protein factor is used. The human genome consists […]

2016-10-24, NEWS

Insulin resistance may reduce monounsaturated fatty acid levels

Insulin resistance and impaired pancreatic insulin secretion are the main precursors of type 2 diabetes and can cause cardiovascular disease. Researchers from Uppsala University/SciLifeLab led by Tove Fall and her doctoral student Christoph Nowak have brought together plasma metabolomics data from several international cohorts to identify metabolic pathways related to insulin resistance and impaired insulin […]

2016-10-19, NEWS

Four SciLifeLab researchers get support from the Ragnar Söderberg Foundation

Ragnar Söderberg Fellowships in Medicine are awarded by the Ragnar Söderberg Foundation and supports promising young researchers at the beginning of their career, facilitating the establishment of a research group and enabling independence. The granted researchers get SEK 8 million for 5 years. This year, four out of five granted researchers are SciLifeLab Fellows, active […]

2016-10-19, PRESS

The first map of genetic variation in Sweden

SciLifeLab today presents the first map of genetic variation in Sweden. The results are based on whole genome DNA sequencing of 1 000 individuals, selected to cover the variation in the whole country. Thanks to this Sweden now has a national resource, which will facilitate research and diagnostics of genetic diseases. The information has today […]

2016-10-18, NEWS

Ancient fish illuminates one of the mysteries of childhood

Remember dropping your milk teeth? After a lot of wiggling the tooth finally dropped out. But in your hand was only the enamel-covered crown: the entire root of the tooth had somehow disappeared. In a paper published in Nature, a team of researchers led by Per Ahlberg, Uppsala University/SciLifeLab, apply synchrotron x-ray tomography to a […]

2016-10-18, NEWS

Chameleonic properties make large molecules into possible drugs

In a paper published today in Nature Chemical Biology, a team of researchers from Uppsala University/SciLifeLab, the Broad Institute of MIT, Harvard, and AstraZeneca are presenting new insights into how larger-than-average molecules can be developed into pharmaceutical drugs. Read full press release Read scientific article

2016-10-17, NEWS

Low cost method for examining single leukemia cells

Leukemia is a disease in which each cell can exhibit different genetic traits, and now a research team led by Joakim Lundeberg, KTH Royal Institute of Technology/SciLifeLab, have found a cheap way to examine individual leukemia cells, which could transform leukemia treatment. The findings were reported in Nature Communications. Read news article Read scientific article

2016-10-17, NEWS

Droplet partitioning improves whole genome amplification

Most of the world’s microbial diversity remains unknown, and it is now well established that traditional laboratory cultivation will not be sufficient to detect the vast majority of these unknown species. When studying environments with very low content of biomass the amounts of DNA that can be extracted may be too scarce to allow standard […]

2016-10-12, NEWS

Apply now for bioinformatics long-term support

Bioinformatics Long-term support (WABI) offers a senior bioinformatician to work in your project for up to 500 hours. The support is fully subsidized and free of charge, but extensive hands-on involvement is required by the applying research groups. Note that a part of this call will focus on early involvement in integrative omics projects, see […]

2016-10-06, NEWS

Roundworms even more useful than researchers previously thought

The one millimetre long roundworm Caenorhabditis elegans has been used as a model organism in scientific research, and has therefore been extensively examined. A research group led by Lena Kjellén, Uppsala University/SciLifeLab, has now demonstrated that the worm is an even more complete model system than previously thought, which could enable more detailed research into […]

2016-10-05, NEWS

Nominate your favorite speaker

SciLifeLab The Svedberg Seminar series is a distinguished speaker series within the field of biosciences and holds research seminars given by leading scientists from Sweden and worldwide. SciLifeLab The Svedberg committee now invites you to nominate speakers of your interest. This is an excellent opportunity for your research group and students to extend their network and engage in […]

2016-09-28, NEWS

Improved method for gene function analysis developed

Researchers at Stockholm University/SciLifeLab have developed a new computer algorithm, called BinoX, for analyzing gene function. The method, developed by Professor Erik Sonnhammer’s research group, associates experimentally derived gene lists and known pathways in a new way. The article was published in Nucleic Acids Research. Read scientific article Read full press release

2016-09-27, NEWS

The Fernström Prize to Jiri Bartek

Jiri Bartek, Karolinska Institutet/SciLifeLab has been awarded The Fernström Prize (Fernströmpriset) together with Jiri Lukas, Novo Nordisk Foundation Center for Protein Research at University of Copenhagen. They receive SEK 1 million for their research on DNA damage. The Fernström Prize is a series of annual awards for prominent Swedish and Nordic scientists in medicine. The prize money is […]

2016-09-20, NEWS

Artificial intelligence reveals mechanism behind brain tumor

Researchers at Uppsala University have used computer modeling to study how brain tumors arise. The study, which was led by Sven Nelander, Uppsala University/SciLifeLab, and published in the journal EBioMedicine, illustrated how researchers in the future will be able to use large-scale data to find new disease mechanisms and identify new treatment targets. Read full […]

2016-09-20, NEWS

Possible vascular drug targets and biomarkers mapped

This study, published in Cell Systems, reveals new vascular drug targets and potential biomarkers of vascular disease. In addition it provides a platform from which to increase our understanding of the vasculature, through the investigation of the function of the unknown genes –which are likely to have a role in the specilised function of the endothelium.

2016-09-16, NEWS

New insights on how brain tumors spread and become resistant to therapy

Fredrik Swartling’s group at Uppsala University/SciLifeLab and Olle Sangfelt group at Karolinska Institutet have jointly discovered that the usually protective protein FBW7 is commonly mutated and inactivated in brain tumor cells in children. This leads to a block of degradation of the stem cell protein SOX9 and gives rise to tumors that spread more easily […]

2016-09-08, NEWS

New insights in the life of early tetrapods

Using synchrotron X-rays a team from Uppsala University/SciLifeLab, the European Synchrotron Radiation Facility (ESRF) in France and the University of Cambridge in the UK decided have investigated fossils of the tetrapod Acanthostega, which lived 360 million ago. Their findings, presented in Nature, show that all skeletons in a mass-death deposit of Acanthostega in Greenland came from juvenile individuals […]

2016-09-06, NEWS

Guidelines for antibody validation proposed by international group

An international working group led by Mathias Uhlén, KTH Royal Institute of Technology/SciLifeLab, has formulated directives to evaluate antibodies used in biomedical research. A paper in Nature Methods suggests five conceptual pillars for antibody validation. Read full press release (in Swedish) Read scientific article

2016-09-05, NEWS

Biobank storage time as important as age

The amount of time a blood sample used for medical research has been stored at a biobank may affect the test results as much as the blood sample provider’s age. These are the findings of a new study led by Ulf Gyllensten, Uppsala University/SciLifeLab, which was published in EBioMedicine. Until now, medical research has taken […]

2016-09-05, NEWS

All time high applications for Science & SciLifeLab Prize

Since the first award in 2013 Science & SciLifeLab Prize for Young Scientists has never received more applications than this year. In total there has been 71% increase of submissions over the years. “We are very happy that the word is obviously spreading about the prize” Says David Gotthold, project leader for Science & SciLifeLab […]

2016-09-02, NEWS

Dual functioning enzyme controls molecule with key role i foetal development

Heparan sulphate occurs as carbohydrate chains which are very important for human body cells both for normal foetal development and during the course of various diseases. All new molecular knowledge concerning these chains is therefore important. A study led by Lena Kjellén, Uppsala University/SciLifeLab, now show that the same enzyme which determines the charge pattern […]

2016-09-02, NEWS

Three SciLifeLab Fellows get ERC Starting Grants 2016

No less than three of the SciLifeLab Fellows have received starting grants from the European Research Council, ERC, 2016. Magda Bienko, Karolinska Institutet/SciLifeLab, Sebastian Deindl, Uppsala Universitet/SciLifeLab and Simon Elsässer, Karolinska Institutet/SciLifeLab all get up to EUR 1.5 million for up to 5 years. ERC Starting Grants are designed to encourage young talented research leaders […]

2016-09-02, NEWS

Cryo-EM open for applications

We are pleased to announce the call for proposals to perform single particle cryo-EM analysis at SciLifeLab national facility for the allocation period November 2016 to February 2017.  The deadline for proposals submission is October 1st. Applications can be submitted via Proposals will be peer-reviewed and selected competitively according to the strength of the scientific case […]

2016-09-01, NEWS

Starting round two of joint Master’s programme

This week SciLifeLab welcomes new students to the Master’s programme in Molecular Techniques in Life Science. It is a unique collaboration between the three Stockholm universities; Karolinska Institutet, KTH Royal Institute of Technology and Stockholm University, and is to a large extent given in the environment of SciLifeLab. The Master’s programme in Molecular Techniques in […]

2016-09-01, NEWS

Cell lines for studying glioma got mixed up

Results from a study published in Science Translational Medicine show that the publicly available cell line U87MG does not originate from the cell line it is claimed to do. The original cell line was established in Uppsala almost fifty years ago. Using genetic analyses, Bengt Westermark at Uppsala University/SciLifeLab and colleagues could show that U87MG actually had […]

2016-08-31, NEWS

They predict superfast protein movement

Researchers at KTH Royal Institute of Technology, Stockholm University and Institute for Biomedical Research Barcelona have developed a minimalistic algorithm that predicts how proteins move to perform their biological function. The work demonstrates that protein motion is dictated by their overall shape, and will improve the understanding of how proteins function and in the long […]

2016-08-26, NEWS

New insights in how tumors metastasise

The growth of cancerous tumors is affected by the growth factor TGF-beta. It both suppresses and stimulates tumor development, but it has not been understood how this happens. A new study led by Carl-Henrik Heldin, Uppsala Universitet/SciLifeLab and Chair of the SciLifeLab Board, reveals important details behind this process. The study was published in Science […]

2016-08-24, NEWS

Metabolically healthy obesity partly a myth

Previous studies have shown that people with obesity display large differences in risk factors for type 2 diabetes. These results have given rise to the theory about “metabolically healthy obesity”. A new study led by Carsten Daub, Karolinska Institutet/SciLifeLab, Mikael Ryden, Karolinska Institutet and Peter Arnér, Karolinska Institutet, now shows that this kind of “harmless” […]

2016-08-23, NEWS

Genes responsible for risk of heart attack and stroke identified

Thousands of genes and their interactions across tissues mediating cardiometabolic diseases have been identified. The research, published in Science, is a result of a joint collaboration between the Icahn School of Medicine at Mount Sinai, Tartu University Hospital in Estonia, SciLifeLab / Karolinska Institutet in Sweden, and AstraZeneca. Read the scientific article in Science Read […]

2016-08-22, NEWS

Cell cycle regulation unveiled

Fast growing bacteria cells do not have time to copy their whole DNA before they divide again. This means that there are several copying processes ongoing at the same time in a bacteria. Researchers at SciLifeLab / Uppsala University headed by Johan Elf have used a combination of microfluidics and image analysis of E. coli […]

2016-08-18, NEWS

A Drug Discovery and Development platform review

A review article focusing on the Drug Discovery and Development platform has been published in Drug Discovery Today. The article describes the origin of the platform as well as it’s purpose and structure. Highlights SciLifeLab DDD platform reaches out to Swedish academia with an industry-standard infrastructure for academic drug discovery. The Swedish Teacher Exemption Law, […]

2016-07-13, NEWS

SNP&SEQ contributes to large diabetes study

The SciLifeLab platform NGI Uppsala (SNP&SEQ Technology Platform) has contributed to a large collaborative study which shows that type 2 diabetes is predominantly driven by common risk variants that are widely shared both within and between populations. NGI Uppsala has contributed to a large collaborative study of the genetic architecture of type 2 diabetes (T2D) conducted […]

2016-07-04, NEWS

New method provides better information on gene expression

A collaboration between professors Joakim Lundeberg, KTH Royal Institute of Technology/SciLifeLab and Jonas Frisén, Karolinsk Institutet, has resulted in a novel high-resolution method for studying which genes are active in a tissue. A great number of scientists connected to SciLifeLab also contributed to the article, which was are published in Science. The method can be used on all types […]

2016-06-29, NEWS

Collaboration is key to efficient tracing of infectious diseases

Using the latest DNA technology disease outbreaks can be tracked and mapped more effectively than before. But Swedish authorities, the health care sector and researchers need to collaborate closely to employ these technologies according to a report from SciLifeLab, Uppsala University and the National Veterinary Institute (SVA). Being one of the largest centers for the […]

2016-06-29, NEWS

New tool for sequencing quality control

The National Genomics Infrastructure, NGI, at SciLifeLab is responsible for sequencing a large number of projects for users across Sweden. A new tool, published in Bioinformatics by Phil Ewels and colleagues at the NGI, allows the facility and users to summarize analysis results for an entire project in a single report. Quality control is critical for anyone involved in […]

2016-06-28, NEWS

Mannose levels shows diabetes risk regardless body weight

No matter if you are overweight or not, the level of the sugar mannose in your blood can reveal if you are at risk of developing type 2 diabetes, according to a study by researchers at KTH Royal Institute of Technology/SciLifeLab. Read full press release. 

2016-06-27, NEWS

Two platforms renamed

Following a decision from the board, two SciLifeLab platforms now have new names: National Bioinformatics Infrastructure Sweden, NBIS (former Bioinformatics) Next-Generation Diagnostics, NGD (former Clinical Diagnostics) NBIS provides custom-tailored support beyond the predefined analyses typically offered by the data-generating platforms at SciLifeLab. The NBIS platform also provides computing and storage resources for large-scale biological data in […]

2016-06-14, NEWS

New insights in evolution of vertebrate vision

A new study published in BMC Evolutionary Biology by the team lead by Xesús Abalo and Dan Larhammar, Department of Neuroscience and SciLifeLab at Uppsala University, sheds light on the evolutionary origin of vertebrate vision and the specialisations in zebrafish to adapt to changing lighting conditions. Light perception is crucial for the survival of all […]

2016-06-13, NEWS

Users welcome to test beta single cell protein panel

The SciLifeLab Single Cell Proteomics facility and Olink Proteomics are excited to announce the launch of a beta testing initiative. We invite individuals from the Swedish academic scientific community to test a prototype single cell 92plex panel of proximity extension assays (PEA) targeting proteins involved in a number of cellular processes, including differentiation, proliferation and […]

2016-06-10, NEWS

Nerve-insulating cells more diverse than previously thought

Oligodendrocytes, a type of brain cell that plays a crucial role in diseases such as multiple sclerosis, are more diverse than have previously been thought, according to a new study led by Sten Linnarsson, Karolinska Institutet/SciLifeLab and Gonçalo Castelo-Branco, Karolinska Institutet. The findings, published in the journal Science , will help increase our understanding of […]

2016-06-10, NEWS

How honeybees do without males

An isolated population of honeybees, the Cape bees, living in South Africa has evolved a strategy to reproduce without males. A research team led by Mathew Webster at Uppsala University/SciLifeLab has sequenced the entire genomes of a sample of Cape bees and compared them with other populations of honeybees to find out the genetic mechanisms […]

2016-06-09, NEWS

Genetic test reveals carriers of gene causing skeletal abnormality

The genetic defect causing skeletal abnormalities in Shetland ponies has been identified by researchers at Uppsala University and Swedish University of Agricultural Sciences (SLU). The gene sequencing in the study was performed at SciLifeLab facility NGI-Uppsala. The discovery, published in the scientific journal G3, makes it possible to detect healthy carriers of the mutated gene which will help […]

2016-06-07, NEWS

Johan Elf to KVA

Johan Elf, Professor of Physical Biology at Uppsala University and Member of the SciLifeLab Management Group, has been elected Member of the The Royal Swedish Academy of Sciences (KVA). Kálmán Szabó, Stockholm University, and Pernilla Wittung-Stafshede, Chalmers University of Technology were also elected as Swedish Members together with Michael Tomasello, Max Planck-institute for evolutionary anthropology, Germany, […]

2016-06-02, NEWS

SciLifeLab opened up for visitors in Uppsala

On June 1:st SciLifeLab held an Open House for the third time, this time in Navet in Uppsala. “Our aim is to reach awareness around the technologies and expertise we offer to researchers from all of Sweden.” Said Eva Molin, Project Coordinator at SciLifeLab. During the day visitors were given the opportunity to meet and listen […]

2016-05-24, NEWS

Time to apply for bioinformatics support

Do you need an experienced bioinformatician in your project to analyse data? Bioinformatics Long-term Support (WABI) offers free support for at least 3 months effective time. Last day for application is October 6. More information and application form is found here.

2016-05-24, NEWS

Loss of Y chromosome in blood cells associated with Alzheimer’s disease

Men with blood cells that do not carry the Y chromosome are at greater risk of being diagnosed with Alzheimer’s disease according to a study by researchers at Uppsala University/SciLifeLab. The new findings could lead to a simple test to identify those at risk of developing Alzheimer’s disease. The study was published in American Journal of Human Genetics. Read […]

2016-05-23, NEWS

Update on chemical accident

The internal investigation of what caused the chemical smell followed by evacuation of the Alfa building in Solna on May 12 has led to a theory about the sequence of events. “We think it started with an accidental spill of xylene in a hood”, Said Fredrik Sterky, Site Manager of SciLifeLab in Stockholm. “When the […]

2016-05-18, NEWS

Second gene modifies effect of mutation in dog model of ALS

Canine Degenerative Myelopathy (DM) is a neurodegenerative disease in dogs with similarities to ALS in humans. An international team of scientists coordinated from Uppsala University, have discovered a modifier gene that affects the risk of developing DM. The study was led by Kerstin Lindblad-Toh and published in PNAS this week. Read press release  

2016-05-17, NEWS

New insights in human brain tumors thanks to dogs

A research team led by Kerstin Lindblad-Toh at Uppsala University/SciLifeLab has used genetic analyses of 25 different dog breeds to identify genes that could have a role in the development of brain tumors. The researchers could identify an area in the genome that differed between diseased and healthy dogs. In this area of the genome […]

2016-05-17, NEWS

Analysis of dog genes help researchers understand human breast cancer

A study published in PLOS Genetics, led by Kerstin Lindblad-Toh at Uppsala University/SciLifeLab, sheds new light on the genetics behind breast cancer. In the first study, the researchers have used technologies at the SNP&SEQ Technology Platform at SciLifeLab to compare genes from healthy dog individuals with genes from individuals with breast cancer. One gene that […]

2016-05-16, NEWS

She is Interim Director of Infrastructure

The SciLifeLab Board has appointed Annika Jenmalm Jensen, Karolinska Institutet/SciLifeLab Interim Director of Infrastructure. The post has been vacant since autumn 2015. Annika Jenmalm Jensen has until know been Platform Director of the SciLifeLab platform Chemical Biology Consortium Sweden (CBCS). She was also Facility Director and Head of facility for the SciLifeLab facility Laboratories for […]

2016-05-13, NEWS

Alfa house safe after chemical leak

At lunchtime May 12, a strong chemical smell was detected in the Alfa building at Tomtebodavägen 23 in Solna. The building, housing around 400 researchers and personnel, was evacuated. A few persons were exposed to the chemical and felt ill and dizzy. They were taken care of by the ambulance personnel outside the building and […]

2016-05-09, NEWS

Genetic test predicts serious adverse reaction to hyperthyroidism treatment

An international research team led by Mia Wadelius, Uppsala University/SciLifeLab, have found gene variants that predict the risk of a serious adverse reaction to drugs used for the treatment of hyperthyroidism. The results were published in The Lancet Diabetes & Endocrinology. Read full news article

2016-05-03, NEWS

The herring genome provides new insight on how species adapt to their environment

How species genetically adapt to their environment is a central question related to the evolution of biodiversity. In a new study scientists at SciLifeLab/Uppsala University and their colleagues report that whole genome sequencing of Atlantic and Baltic herring revealed hundreds of loci underlying adaptation to the brackish Baltic Sea or timing of reproduction. The study […]

2016-05-02, NEWS

The role of sequencing in disease control

Today SciLifeLab and the National Veterinary Institute organized a workshop on clinical applications of novel sequencing technologies for disease surveillance. The workshop aimed to enable an exchange of experience on the opportunities and challenges that Next Generation Sequencing (NGS) poses in the daily operations of the Swedish health care, authorities involved in disease control, as […]

2016-04-28, NEWS

The power of a single cell

The theme for today’s SciLifeLab Science Summit was single cell analyses, from microbes to human brain. A number of researchers both from within and outside of SciLifeLab highlighted this complex subject and offered insight into their research.   Olli Kallioniemi, Director of SciLifeLab, introduced the summit with a summary of what is currently going on […]

2016-04-22, NEWS

New board for SciLifeLab

The board at KTH Royal Institute of Technology has, in consultation with Karolinska Institutet, Stockholm University and Uppsala University, appointed four representatives from the four host universities together with three representatives from other Swedish universities. The following representatives from the host universities have been appointed: Sophia Hober, KTH Royal Institute of Technology Henrik Grönberg, Karolinska […]

2016-04-22, NEWS

Evolution in action detected in Darwin’s finches

The most characteristic feature of Darwin’s finches is the diversification of beak morphology that has allowed these species to expand their utilization of food resources in the Galápagos archipelago. A team of scientists from SciLifeLab/Uppsala University and Princeton University has now identified a gene that explains variation in beak size within and among species. The […]

2016-04-20, NEWS

Pilot facilities approved

The Steering group of SciLifeLab in Stockholm has decided to approve 8 projects at Karolinska Institutet, KTH Royal Institute of Technology and Stockholm University to become pilot facilities at SciLifeLab.

2016-04-12, NEWS

New version of the Human Protein Atlas released

The Human Protein Atlas consortium has launched version 15 of the database including extensive transcriptomics data. For the first time, the database has also been compared with data generated at Broad Institute. The Human Protein Atlas is a multinational research project led by Mathias Uhlén, KTH Royal Institute of Technology/SciLifeLab. The project is supported by […]

2016-04-08, NEWS

Genomewide CRISPR-Cas9 screenings identify a novel mechanism of resistance to anticancer therapies

Resistance to chemotherapy is a common finding in the clinic, which limits the efficacy of anti-cancer therapies. Oscar Fernandez-Capetillo, Karolinska Institutet/SciLifeLab, and colleagues, have explored how mammalian cells might become resistant to chemical inhibitors of ATR, a molecule involved in sensing DNA damage. Using mouse genetics, the group has previously shown that limited ATR activity […]

2016-04-05, NEWS

Nominate your favorite speaker

SciLifeLab The Svedberg Seminar series is a distinguished speaker series within the field of biosciences and holds research seminars given by leading scientists from Sweden and worldwide. SciLifeLab The Svedberg committee now invites you to nominate speakers of your interest. This is an excellent opportunity for your research group and students to extend their network and engage in scientific […]

2016-04-04, NEWS

Two prestigious grants to SciLifeLab researchers

Thomas Helleday, Karolinska Institutet/SciLifeLab is one of nine Swedish researchers who have been granted funding from the 2015 call from the European Research Council, ERC. A total of 34 Swedish life science researchers applied for the ERC Advanced Grant and five of these applications were approved. The granted PIs, who are established researchers considered to be […]

2016-04-04, NEWS

Anna Wedell new chair of the Nobel Committee for Physiology or Medicine

The Nobel Assembly at Karolinska Institutet has appointed Anna Wedell, Karolinska Instituet/SciLifeLab, chair of the Nobel Committee for Physiology or Medicine for 2016. She replaces Thomas Perlmann, who is to become secretary of the Nobel Assembly at Karolinska Institutet and the Nobel Committee for Physiology or Medicine. Read full news article

2016-03-30, NEWS

Gold and ultrasound burst improves sensitivity in antibody microarray analysis ten thousand fold

Antibody microarrays are powerful tools for simultaneous detection of hundreds or thousands of blood-borne protein biomarkers at once, potentially allowing accurate fingerprinting and improved diagnostics of complex pathophysiological states such as cancers, neurodegenerative diseases and autoimmune conditions. However, to enable sensitivity needed to detect low abundant protein biomarkers such as cytokines and tissue leakage proteins, […]

2016-03-30, NEWS

Probing intracellular target engagement in live cells

Biological responses of small molecules are a direct consequence of their interactions with intended target proteins, as well as unwanted off-targets. Direct measurement of such compound target engagement in a cellular or tissue context has traditionally been difficult to establish without the development of specific tool compounds and/or protein modifications with reporter functionalities. As this […]

2016-03-23, NEWS

Decreased blood vessel leakage can improve cancer therapy and reduce tumour spread

Cancer therapy is often hampered by the accumulation of fluids in and around the tumour, which is caused by leakage from the blood vessels in the tumour. Researchers at SciLifeLab / Uppsala University now show how leakage from blood vessels is regulated. They have identified a novel mechanism whereby leakage can be suppressed to improve […]

2016-03-16, NEWS

Kristina Persson visited SciLifeLab

Kristina Persson, Minister for Strategic Development and Nordic Cooperation, visited SciLifeLab in Uppsala on March 11. The program is available here.

2016-03-09, NEWS

Research becomes computer-game

Project Discovery aims to employ the general public to help scientists make new discoveries through EVE online, a massive multiplayer online role-playing game. Emma Lundberg at KTH Royal Institute of Technology/SciLifeLab has cooperated with two game companies to engage gamers in her research project. Computer- and TV games are not just fun but have also been shown […]

2016-03-07, NEWS

A new traffic-policeman regulates the recruitment or exclusion of proteins from sites of DNA replication

In 2013, Oscar Fernandez-Capetillo, currently at Karolninska Institutet/SciLifeLab, and co-workers performed the first proteomic analysis of the human replisome (Lopez-Contreras et al Cell Reports 2013). Besides providing a panoramic view of the proteins that are enriched around sites of DNA replication, this work noted an interesting phenomenon. Human proteins are “flagged” by being linked to […]

2016-03-02, NEWS

SciLifeLab researcher receives Gustaf Adolfs prize

Lena Claesson-Welsh, Acting Co-Director at SciLifeLab, has received this years Gustaf Adolfs prize. Read the motivation

2016-02-17, NEWS

Multidisciplinary effort for autoimmune diseases

The recently launched research project Relent aims at developing new, individualized therapies for autoimmune diseases like rheumatism and multiple sclerosis. The project will be carried out by a multidisciplinary consortium of nine scientific partners and four SME’s from Europe, the US and Australia. Among the partners is KTH Royal Institute of Technology/SciLifeLab where the research […]

2016-02-17, NEWS

New microbes that thrive deep in the earth discovered

They live several kilometers under the surface of the earth, need no light or oxygen and can only be seen in a microscope. By sequencing genomes of a newly discovered group of microbes, the Hadesarchaea, an international team of researchers have found out how these microorganisms make a living in the deep subsurface biosphere of […]

2016-02-04, NEWS

New virus-based treatment goes into clinical trial

Magnus Essand and Justyna Leja at SciLifeLab/Uppsala University has together with their colleagues developed a new treatment for tumors, using viruses. The treatment will now go into clinical trial. Read the full press release at Uppsala University Read more about Magnus Essand’s research group

2016-01-27, NEWS

New center for studying the human microbiome

Ferring Pharmaceuticals and Karolinska Institutet have signed a collaboration agreement for the establishment of a research center exploiting the human microbiome. Parts of the research will be carried out at SciLifeLab, providing access to a broad technical platform for studying complex microbiological communities in well-defined human material. The programme will be fully funded by Ferring Pharmaceuticals and led […]

2016-01-21, NEWS

Call for proposals for pilot facilities at SciLifeLab Uppsala 2016

SciLifeLab in Uppsala now opens a call for proposals for new pilot facilities, not currently part of SciLifeLab. Researchers at Uppsala University can apply with the aim to set up and provide an outstanding service of a technology relevant for researchers in the life sciences. SciLifeLab strives to develop and provide frontline technology for the […]

2016-01-20, NEWS

Paper from KTH/SciLifeLab number 16 on global citation list

In competition with a couple of million scientific articles, a paper published by researchers at KTH/SciLifeLab was ranked number 16 on the database Web of Science listing of the worlds’ most cited articles 2015. The article, Tissue-based map of the human proteome, is one of 340 papers published by researchers in the Human Protein Atlas […]

2016-01-14, NEWS

Closest relatives of Baltic Sea plankton found in North American waters

A study published in Genome Biology, led by Anders Andersson at KTH Royal Institute of Technology/SciLifeLab, shows that the closest relatives of bacterial plankton in the Baltic Sea are not found in oceans or freshwater lakes, but in other brackish environments. The researchers used DNA sequencing and advanced algorithms to reconstruct the genomes of a number of bacterial plankton. The […]

2016-01-12, NEWS

Thomas Helleday is Cancer researcher of the year

Thomas Helleday, Professor in Chemical Biology at Karolinska Institutet/SciLifeLab has been awarded Årets cancerforskare (Cancer researcher of the year) by Cancerfonden. The award ceremony took part at the fundraising gala Nej till cancer (No to cancer) that was broadcast live in TV4 January 11. Read more about Årets cancerforskare (in Swedish).  

2016-01-07, NEWS

Effects of drug therapy on single cells

To understand the functions of our body organs in health and disease, it is necessary to study the molecular composition of individual cells that make up the organ’s cell communities in the organs. SciLifeLab/Uppsala University researchers have developed an approach to analyze the highest number so far of proteins in single human cells. Almost 100 […]