Chemical Biology Consortium Sweden (CBCS)National facility
The Chemical Biology Consortium Sweden (CBCS) is a state-of-the-art national research infrastructure for (academic) investigators throughout Sweden. CBCS coordinates, and makes available, a powerful and integrated platform for the discovery, development and utilization of small molecules and chemical tools for life science applications in close collaboration with research groups to explore biology.
CBCS was established in 2010 as a nation-wide infrastructure for chemical biology research consisting of two facilities, at Karolinska Institutet, Stockholm (LCBKI), and at Umeå University (LCBU). In 2012, CBCS became an integrated platform at SciLifeLab. CBCS is currently part of the Chemical Biology and Genome Engineering platform at Scilifelab. To pursue our mission in helping our users advance their research, we encourage and drive collaborations with other facilities or platforms.
For more Information on Chemical Biology, CBCS news, Events or High-Throughput Screening courses, etc., please visit our website.
Our facility at Scilifelab comprises compound handling labs, hosting Echo liquid handlers and the Scilifelab Compound Collection of about 200,000 molecules. Through the Compound Center, compound requests can be placed in the Compound Portal.
The facilities further host screening labs (microtiter format liquid handling robotics, a wide range of plate readers and a high-content imager connected to robotics), and chemistry labs (equipment and instrumentation for organic chemistry synthesis and analysis).
- Access to small-molecule compound libraries and robotic instrumentation
- Expertise in assay development and automation
- High-throughput screening: biochemical target-based, cell-based and phenotypic
- High-throughput imaging technology
- Expertise in screening for antimicrobial compounds and plant-based screens
- Hit identification and optimization
- Computational chemistry and modelling
- Medicinal chemistry expertise
- Chemical proteomics & target identification of small molecule ligands
- Mechanism of Action studies
For more Information on our available services, visit our website.
CBCS works according to a collaborative research model based on mutual commitment from our group and the involved Investigator.
For more substantial projects, a formal process initiated by an application is implemented to ensure that resources are prioritized based on transparent criteria, such as scientific excellence, novelty, technical feasibility and relevance. Our Project Review Committee (PRC) consists of CBCS-independent experts in the chemical biology research field, also including industry representation.
For more information on project collaborations, our cost model, as wells as upcoming deadlines for PRC submissions please refer to our website.
CBCS houses a number of instruments and equipment, which are also available for use through our open-access policy.
For more Information on our instrumentation, please visit our website.
Our users come from all Swedish Universities, with new first contact meetings taking place on a weekly basis. Our projects comprise Technology development projects, chemistry designs and small molecule screens with therapeutic focus on isolated target proteins, screens for finding tools in plant research or phenotypic screens.
A full CBCS publication list on completed projects can be found in the Scilifelab publication database.